Nucleic Acids Res. 43, e17 (2015). Article CAS PubMed Google Scholar Han, J. et al. Efficient in vivo deletion of a large imprinted lncRNA by CRISPR/Cas9. RNA Biol. 11, 829–835 (2014). Article CAS PubMed PubMed Central Google Scholar Eißmann, M. et al. Loss of the ...
Free radicals and other so-called ‘reactive species’ are constantly produced in the brainin vivo. Some arise by ‘accidents of chemistry’, an example of which may be the leakage of electrons from the mitochondrial electron transport chain to generate superoxide radical (O2−). Others are g...
Ageing is a complex, multifaceted process leading to widespread functional decline that affects every organ and tissue, but it remains unknown whether ageing has a unifying causal mechanism or is grounded in multiple sources. Phenotypically, the ageing process is associated with a wide variety of fea...
1). Generally, EVs play a significant role in cellular dumping or the release of waste materials. EVs deliver various cargoes, including mRNAs, microRNAs (miRNAs), lipids, proteins, and nucleic acids, for long-distance communication between cells [3, 4]. Pathological cells, such as cancer ...
The uropathogenic role of Prc was determined in a mouse model of UTIs. Using global quantitative proteomic analyses, we revealed that the expression of FliC and other outer membrane-associated proteins was altered by Prc deficiency. Comparative transcriptome analyses identified that Prc deficiency affecte...
In the first phase, the body tries to eliminate the virus using regulated immune response in the early asymptomatic and non-severe disease stages, preventing progression to the severe stage. In the second phase, there is an inflammatory cytokine storm and hyper-activation of the immune system ...
These include the cell surface and endosomal Toll-like receptors (TLRs), as well as a variety of cytosolic PRRs such as RIGI, MDA5, and IFI16 that primarily bind viral nucleic acids (136). Following ligand binding, PRRs share a number of downstream signaling intermediates, that ultimately ...
DNA cytosine methylation is a widely conserved epigenetic mark in eukaryotes that appears to have critical roles in the regulation of genome structure and transcription. Genome-wide methylation maps have so far only been established from the supergroups
et al. Visualizing formation of the active site in the mitochondrial ribosome. Elife 10, e4578 (2021). Kim, H. J. & Barrientos, A. MTG1 couples mitoribosome large subunit assembly with intersubunit bridge formation. Nucleic Acids Res. 46, 8435–8453 (2018). Article CAS PubMed PubMed ...
Diabetic cardiomyopathy (DCM) is one of the common cardiovascular complications of diabetes and a leading cause of death in diabetic patients. Mitochondrial metabolism and immune-inflammation are key for DCM pathogenesis, but their crosstalk in DCM remai