Archives of Biochemistry & BiophysicsDiscussion, p. 25-26. In: The structure of nucleic acids and their role in protein synthesis - CRICK - 1957Crick FHC. 1957. Discussion, in The structure of nucleic acids and their role in protein synthesis. Biochem Soc Symp 14: 25-26....
of emerin, an integral protein of the nuclear envelope, abolishes preferential localization of several nuclear proteins. We propose that the frontally biased localization of the endoplasmic reticulum, through which emerin reaches the nuclear envelope, is sufficient to generate its observed bias. In ...
Loss of either leads to reduced levels of 16S rRNA, a reduction in mitochondrial protein synthesis and consequently cell growth. Both, GTPBP5 and GTPBP10 can complement for loss of ObgE in E. coli18, but have nonoverlapping, essential functions in human mitoribosome biogenesis14,15,16,17. ...
Here, we demonstrate that moderate mitochondrial superoxide and hydrogen peroxide production oxidates KEAP1, thus breaking the interaction between this protein and PGAM5, leading to the inhibition of its proteasomal degradation. Accumulated PGAM5 interferes with the processing of the PINK1 in the ...
[210]. However, Kim et al. showed that radiation-activated mTOR and elicited de novo protein synthesis instead of autophagy [211] implying a context-dependent regulation of mTOR and autophagy. Besides autophagy, cathepsins also mediate radioresistance in tumor cells. Elevation of cathepsin B [212...
The nucleolus is primarily the site of ribosomal RNA (rRNA) synthesis and ribosome assembly. It is the most transcriptionally active cellular organelle due to its repetitive sequences of ribosomal DNA (rDNA) genes [8]. The high content of nucleic acids and ribosomal proteins creates a unique ...
The RCAN1.4-calcineurin/NFAT signaling pathway is essential for hypoxic adaption of intervertebral discs Article Open access 29 May 2020 References Kaelin, W. G. The von Hippel–Lindau tumour suppressor protein: O2 sensing and cancer. Nat. Rev. Cancer 8, 865–873 (2008). CAS PubMed Google...
However, most of the methylation is found in a CG context (Supplementary Fig. S3a). We detected 3,887 HMRs that together cover 1,412,473 base pair (bp) (~5.16%) of the 27.4-Mb P. tricornutum nuclear genome (Supplementary Table S4). The length of HMRs ranged from 60–5,700 ...
An example of pharmaceutical interest is mycophenolic acid (MPA), an immunosuppressant molecule produced by several Penicillium species. The target of MPA is inosine-5'-monophosphate dehydrogenase (IMPDH), which catalyses the rate limiting step in the synthesis of guanine nucleotides. The recent ...
In the past 40 years, there has been increasing acceptance that variation in levels of gene expression represents a major source of evolutionary novelty. Gene expression divergence is therefore likely to be involved in the emergence of incipient species,