The ends of the pri-miRNA are then cleaved by the RNA microprocessor complex composed of the RNA endonuclease Drosha and binding partner DiGeorge syndrome chromosome region protein (DGCR)-8 into the pre-miRNA h
Figure 1. The biogenesis and functions of miRNAs Canonically, miRNA genes are first transcribed by RNA polymerase II (Pol II) in the nucleus, resulting in primary miRNA (pri-miRNAs) transcripts that contain stem-loop structures. Next, the nuclear microprocessor, consisting of RNase III enzyme Dro...
Thus, we further tested the rescue of the phenotype through hemin treatment in cardiomyocytes where Dgcr8 expression was decreased. Hemin, which is a ferric form (Fe3+) of heme and which has been shown to stimulate the microprocessor activity in vitro23,24,25 and in vivo26, has been ...
Crucially, they consist of an array of spring probes, or pins, which electrically connect the microprocessor to the test system, so mimicking the effect of soldering in the finished product. These probes are typically shielded by a plastic housing or ‘insulator case’ to prevent crosstalk ...
Metabolic reprogramming is one of the main characteristics of malignant tumors, which is due to the flexible changes of cell metabolism that can meet the needs of cell growth and maintain the homeostasis of tissue environments. Cancer cells can obtain me
Incom- ing data from the sensor are gathered, stored, and read by this microprocessor which extracts critical information, which would be sent to using GSM and XBee (Zigbee). From 9, the transmitter contains four sensors: a microcontroller, a GSM modem, and an XBee transmitter. When ...
Anyone taking even a casual look at a cell phone knows some kind of processing is going on inside. The display, keypad interface and various other man-machine-interface functions are most often handled by a microprocessor. The control processor is usually embedded in a digital ASIC. While vario...
[25] with the composition presented in Table 1. The pH of the resulting solution was verified by microprocessor-based pH meter (Hanna Instruments, Leighton Buzzard, UK) to be 6.8. The pH of the solution was varied by adding citric acid (Sigma-Aldrich Company, Dorset, UK) to the SAGF ...
In one embodiment, the multiple-role entity60may be embedded into, for example, a digital camera (not shown). A microprocessor of the digital camera60may be selected as the host portion66. In addition, a memory of the digital camera60may be selected as the device portion64. In this case...
The illustrated mobile device902can include a controller or processor910(e.g., signal processor, microprocessor, ASIC, or other control and processing logic circuitry) for performing such tasks as signal coding, data processing, input/output processing, power control, and/or other functions. An ope...