Tissue-resident macrophages and recruited macrophages play pivotal roles in innate immunity and the maintenance of brain homeostasis. Investigating the involvement of these macrophage populations in eliciting pathological changes associated with neurodeg
Summary The macrophage plays an important role in both the innate and acquired (humoral and cellular) immune responses. Their specialized derivatives, the dendritic cells (DCs), are uniquely potent in induction of naive T and B lymphocytes, whereas macrophages influence a range of immune responses ...
The pathophysiology of NASH is multifactorial and not yet completely understood; however, innate immunity is a major contributing factor in which liver-resident macrophages (Kupffer cells) and recruited macrophages play a central part in disease progression. In this Review, we assess the evidence for...
Its primary function is to stimulate the retention of macrophages at the site of inflammation and thus facilitate the eradication of the pathogen5. This role of MIF might be considered detrimental in the circumstances of, for example, ulcerative colitis. Namely, MIF is highly expressed in the ...
MIF was identified as a major gene product upregulated in breast cancer cells upon coculture with macrophages. TNFα-triggered tumour cell-derived MIF led to increased macrophage metalloproteinase production rates and facilitated tumour cell invasion [32]. To clarify the causal involvement of MIF in...
Role of the Mannose Receptor (CD206) in Innate Immunity to Ricin Toxin The entry of ricin toxin into macrophages and certain other cell types in the spleen and liver results in toxin-induced inflammation, tissue damage and org... E Gage,MO Hernandez,JM O'Hara,... - 《Toxins》 被引量:...
The aim of this work was to characterize the age-related changes in several parameters of oxidative stress and immune function, as well as in lipofuscin accumulation (“a hallmark of aging”), in both total peritoneal leukocyte population and isolated peritoneal macrophages. Adult, mature, old ...
J. Russell Lindsey,H Cassell - 《American Journal of Pathology》 被引量: 110发表: 1973年 Critical Role of Macrophages and Their Activation via MyD88-NFκB Signaling in Lung Innate Immunity to Mycoplasma pneumoniae Accumulation and activation of macrophages were decreased in the lungs of MyD88(-...
Colony-stimulating factor 1 (CSF1) controls the growth and differentiation of macrophages.CSF1R signaling has been implicated in the maintenance of the intestinal stem cell niche and differentiation of Paneth cells, but evidence of expression of CSF1R within the crypt is equivocal. Here we show th...
Galectin-12 enhances inflammation by promoting M1 polarization of macrophages and reduces insulin sensitivity in adipocytes. Glycobiology 26, 732–744 (2016). CAS PubMed Google Scholar Sano, H. et al. Critical role of galectin-3 in phagocytosis by macrophages. J. Clin. Invest. 112, 389–397...