Although profound knowledge has been gained on leukocyte function, the possibility that non-haematopoietic constituents of the immune system may also play an important immunological role was largely ignored for a long time. The reticular network of lymph nodes (LNs) and other immunological organs (e...
It is well established that the immune system is involved in the initiation, development, and progression of cancer. The tumor microenvironment is highly infiltrated by a complex network of immune cells, which includes innate (macrophages, mast cells, neutrophils, dendritic cells, natural killer cells...
The CNS is protected by the immune system, including cells that reside directly within the CNS and help to ensure proper neural function, as well as cells that traffic into the CNS with disease. The CNS-resident immune system is comprised mainly of innate immune cells and operates under homeos...
While a role of T cells has been established in the development of this diseases, the role of the innate immune system is still largely unknown in the development of lung inflammation leading to HP. To study this disease, we used a mouse model of HP, induced by SR, along with Rag/ ...
terminals near, or in direct contact with, lymphocytes in lymphoid organs, including thymus, spleen, lymph nodes, and bone marrow, and the presence of adrenergic receptors on lymphocytes suggest that sympathetic innervation and the transmitter NE may be important in the modulation of immune responses...
Human aging is associated with progressive decline in immune functions, increased frequency of infections. Among immune functions, a decline in T cell functions during aging predominates. In this review, we will discuss the molecular signaling in two maj
Sex influences on the tumour microenvironment (TME) are not well characterised, despite the importance of immune response in CRC. We hypothesised that sex-divergent immune responses could contribute to survival. Methods Using a murine model of metastatic CRC, we examined T cells, macrophages, and ...
The mammalian intestinal tract harbors a diverse community of trillions of microorganisms, which have co-evolved with the host immune system for millions of years. Many of these microorganisms perform functions critical for host physiology, but the host
particularly food proteins and components of the commensal microbiota. When induced via the gut, the latter phenomenon is called “oral tolerance,” which largely depends on the development of regulatory T (Treg) cells in mucosa-draining lymph nodes to which dendritic cells (DCs) carry exogenous ...
Inflammatory Bowel Disease (IBD), a chronic nonspecific intestinal inflammatory disease, is comprised of Ulcerative Colitis (UC) and Crohn’s Disease (CD). IBD is closely related to a systemic inflammatory reaction and affects the progression of many int