We investigated the role of the S4-S5 linker in the activation process by quantifying its interaction with other intracellular regions. To this end, we constructed chimeric channels in which the N-terminus, the S4-S5 linker, the C-linker, and the CNBD of the retinal CNGA1 subunit were ...
Role of the Q-R Linker in H+/Cl- Coupling in a CLC ExchangerNot Availabledoi:10.1016/j.bpj.2009.12.1736Hills, ChristopherBruce, SophieAccardi, AlessioBiophysical Journal
We investigated the contribution of each of the HAMP-like linker regions to the functionality of DhNik1p and found that the HAMP4b linker was essential as its deletion resulted in the complete loss of activity. Replacement of this linker with flexible peptide sequences did not restore DhNik1p...
PKR contains two N-terminal dsRNA binding domains (dsRBD) and a C-terminal kinase domain. The dsRBDs and the kinase are separated by a long, unstructured ~80 amino acid linker in the human enzyme. The length of the N-terminal portion of the linker varies among PKR sequences and it is ...
The role of sensory proces... JL Mirdamadi,HJ Block - 《Journal of Neurophysiology》 被引量: 0发表: 2020年 Identification of a surface charged residue in the S3-S4 linker of the pacemaker (HCN) channel that influences activation gating I(f), encoded by the hyperpolarization-activated cyclic...
Upregulation of sialyltransferases—the enzymes responsible for the addition of sialic acid to growing glycoconjugate chains—and the resultant hypersialylation of up to 40–60% of tumour cell surfaces are established hallmarks of several cancers, includ
We propose that a GPCR via its intracellular loop 2 directly interacts with the β2/β3 loop of Gα to communicate to Linker 2, resulting in the opening and closing of the α-helical domain and the release of GDP during G-protein activation. 展开 ...
Tomohisa Toda, Sarah L. Parylak, Sara B. Linker & Fred H. Gage Molecular Psychiatry volume 24, pages 67–87 (2019)Cite this article 19k Accesses 435 Citations 144 Altmetric Metrics details Abstract Adult neurogenesis in the dentate gyrus of the hippocampus is highly regulated by a number ...
Role of the interdomain linker peptide of Trichoderma reesei cellobiohydrolase I in its interaction with crystalline cellulose. Cellobiohydrolase I (CBH I), the major component of Trichoderma reesei cellulolytic system, is comprised of a catalytic core domain joined to a cellulose b... M Srisodsuk...
-actinin (via its PDZ domain) and has been suggested to function as a linker-strut to maintain cytoskeletal structural integrity during contraction. Cypher may also participate in signaling pathways by binding to protein kinase C via its LIM domains. Analysis of Cypher-deficient mice has revealed ...