We investigated the role of the S4-S5 linker in the activation process by quantifying its interaction with other intracellular regions. To this end, we constructed chimeric channels in which the N-terminus, the S4-S5 linker, the C-linker, and the CNBD of the retinal CNGA1 subunit were ...
T7 DNA primase is composed of a catalytic RNA polymerase domain (RPD) and a zinc binding domain (ZBD) that are connected by an unstructured linker of 16 residues. The two domains are required for initiating the formation of a functional tetraribonucleotide, 5′-pppACCC-3′, from ATP and ...
We investigated the contribution of each of the HAMP-like linker regions to the functionality of DhNik1p and found that the HAMP4b linker was essential as its deletion resulted in the complete loss of activity. Replacement of this linker with flexible peptide sequences did not restore DhNik1p...
2) [14]. While 4F2hc involves in the movement of the heterodimer to the plasma membrane, xCT determine the substrate specificity and link to 4F2hc with a disulfide linker to play the role. After imported into cells, cystine can be rapidly reduced to cysteine and then participate in the ...
Upregulation of sialyltransferases—the enzymes responsible for the addition of sialic acid to growing glycoconjugate chains—and the resultant hypersialylation of up to 40–60% of tumour cell surfaces are established hallmarks of several cancers, includ
High resolution (31)P nuclear magnetic resonance spectra at 303.6 MHz (corresponding to a (1)H resonance frequency of 750 MHz) have been obtained of perchl... B, Moreno,JA Urbina,E, Oldfield,... 被引量: 0发表: 2021年 Identification of a surface charged residue in the S3-S4 linker of...
1a), showed it could form a coiled-coil in that context, but it was missing the important proximal linker region between the coiled-coil and TM domain. Hence, there is as yet no experimental evidence for either the three-dimensional structure or function of such a CTD in an intact sodium...
In bacteria, the tubulin-like GTPase FtsZ serves as the foundation for the cytokinetic ring. A conserved feature of FtsZ is an intrinsically disordered peptide known as the C-terminal linker. Chimeric experiments suggest the linker acts as a flexible boom allowing FtsZ to associate with the ...
To enhance the catalytic efficiency of graphene quantum dot (GQD) for ORR, the role of S-dopant and S-linker is explored here by utilizing the first-principles density functional theory-based approach. The ORR efficiency is found to be changed on different active sites with the variation of ...
Tomohisa Toda, Sarah L. Parylak, Sara B. Linker & Fred H. Gage Molecular Psychiatry volume 24, pages 67–87 (2019)Cite this article 19k Accesses 144 Altmetric Metrics details Abstract Adult neurogenesis in the dentate gyrus of the hippocampus is highly regulated by a number of environmental ...