aThe kidneys play as important a role in ridding the body of toxins as do the liver and the bowel. They do so by filtering potentially dangerous impurities out of the blood and discarding them daily through the bladder in the form of urine. 肾脏戏剧一样重要在赶走身体的一个角色毒素象肝脏和...
Various substances in the body have an effect on one or more of the above stone forming processes, thereby influencing a person's ability to promote or prevent stone formation. Promoters of stone formation facilitate stone formation whilst inhibitors prevent it. Low urine volume, low urine pH, ...
Kidney diseases represent a diverse range of conditions that compromise renal function and structure which characterized by a progressive deterioration of kidney function, may ultimately necessitate dialysis or kidney transplantation as end-stage treatme
In recent years, the role of EVs in nephrology has garnered considerable attention [14,15,16]. In the context of kidney injury, extracellular vesicles originating from different parts of the kidney play a propelling role in the progression of disease by mediating intercellular communication among d...
If you'd like to find out more about this topic, visit the lesson called The Nephron: Structures, Function & Urine Formation. This lesson goes through the following objectives: Identify the main role of the kidneys Explain how nephrons play a role in urine production ...
On the other hand, the presence of protein in urine is a strong indicator that a patient is likely to experience progressive kidney function decline. Even in the setting of a relatively normal GFR, the proteinuric patient has a high chance of s howing a steep progressive slope of GFR loss...
In addition to suffering the consequences of chronic organ failure, the kidneys and heart produce chemicals that mediate pathophysiological changes in vascular tone, salt and water balance, cellular hypertrophy, and fibrosis underlying these disease processes. The kidneys produce renin in the juxtaglomerul...
Acute kidney injury (AKI), with a high morbidity and mortality, is recognized as a risk factor for chronic kidney disease (CKD). AKI-CKD transition has been regarded as one of the most pressing unmet needs in renal diseases. Recently, studies have showed
[5]. Magnesium is crucial for the formation of bone, favoring calcium assimilation into bones and contributing to the activation of vitamin D in the kidneys [6]. The highest stores of magnesium have been found in bones, followed by muscles, soft tissues, and body fluids. In clinical ...
In rodent models, the inflammatory response to interstitial crystal deposition attracts macrophages, which leads to giant cell formation and may eventually result in crystal elimination. Gene expression studies of kidneys from patients with kidney stones revealed pro-inflammatory macrophage gene signatures, ...