ironred blood cellAnaemia is a major cause of morbidity and mortality worldwide and is often observed in critically ill patients, not just at admission but particularly during intensive care unit (ICU) stay [1]. The time course of anaemia during an ICU stay depends on the underlying ...
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When red blood cells die, their iron is released and carried by transferrin to the bone marrow and to other organs such as the liver and spleen. In the bone marrow, iron is stored and used as needed to make new red blood cells. Once the oxygen is delivered the iron (as part of ...
The role of iron in the immune response to bacterial infection My laboratory has been interested for some time in the influence of iron, a nutrient that is essential for both microbial pathogens and their mammalian hos... BJ Cherayil - 《Immunologic Research》 被引量: 148发表: 2011年 Diversi...
The role of iron and reactive oxygen species in cell death. Nat Chem Biol. 2014;10:9–17. https://doi.org/10.1038/nchembio.1416. Article CAS PubMed Google Scholar Zhou B, Zhang J, Liu X, Chen H, Ai Y, Cheng K, et al. Tom20 senses iron-activated ROS signaling to promote ...
Ferroptosis is an iron-dependent form of non-apoptotic cell death characterized by excessive lipid peroxidation and associated with a plethora of pathological conditions in the liver. Emerging evidence supports the notion that dysregulated metabolic path
Iron Release from Ferritin and Generation of Hydroxyl Radical in the Reaction System of Alloxan with Reduced Glutathione;A Role of Ferritin in Alloxan Toxi... (1988) Iron release from ferritin and generation of hydroxyl radical in the reaction system of alloxan with reduced glutathione; a role ...
The membrane bound enzymes such as Na, K-ATPase, were mostly located in the plasma membrane and pinocytotic vesicles of the endothelium. The administration of cholesterol resulted in the clumping and dispersion of ruthenium red and colloidal iron positive substances in endothelial cells, as well ...
Adequate supply of blood and structural and functional integrity of blood vessels are key to normal brain functioning. On the other hand, cerebral blood flow shortfalls and blood–brain barrier dysfunction are early findings in neurodegenerative disorders in humans and animal models. Here we first ex...
The liver in the human body is positioned between the gastrointestinal tract and the systemic circulation. The human liver receives a blood flow of approximately 1.5 liters per minute. On one hand, the liver obtains blood from the circulation through the hepatic artery, and on the other hand,...