Animal models have shown nutrient-sensing pathways, such as the insulin and insulin-like growth factor1 (IIS), mTOR and sirtuin pathways, can provide the molecular basis for the association between lifestyle and ageing. Furthermore, these pathways have been implicated in stem cell maintenance, su...
Atrial natriuretic peptide and renin-angiotensin-aldosterone system in non–insulin-dependent diabetes mellitus. J Hum Hypertens. 1994;8451- 456PubMedGoogle Scholar 84. Ando SRahman MAButler GCSenn BLFloras JS Comparison of candoxatril and atrial natriuretic factor in healthy men: effects on ...
Atrial natriuretic peptide and renin-angiotensin-aldosterone system in non–insulin-dependent diabetes mellitus. J Hum Hypertens. 1994;8451- 456PubMedGoogle Scholar 84. Ando SRahman MAButler GCSenn BLFloras JS Comparison of candoxatril and atrial natriuretic factor in healthy men: effects on ...
Although the clinical data are not sufficient, animal data suggest that the mechanisms responsible for hyperglycemia with mTOR inhibitors are likely due to the combination of impaired insulin secretion and insulin resistance [58]. Hyperglycemia is essential for the onset of diabetic nephropathy, which ...
hepatic-specific Coxsackievirus B3 Cytochrome P450 family 7 subfamily A member 1 diethylnitrosamine Endoplasmic reticulum Extracellular signal–regulated kinase Fibroblast growth factor General control non-repressed protein 5 Glycogen synthase kinase 3β Rag guanosine triphosphatases Insulin receptor substrate Jumo...
insulin secretion, glycolysis/gluconeogenesis pathways Disable cell proliferation and suppress cell growth Inhibits melanoma cells growth via inhibition of HMGA2 Induction of apoptosis and inhibition of cell proliferation Anticancer activity via suppression of cell growth and invasion; determines increased sensit...