Although 3 hyaluronic acid preparations are commercially available for treating osteoarthritis, there is still considerable uncertainty regarding the optimal use of this therapy. A discussion of trials conducted to date, and the results of 2 new placebo-controlled studies, were discussed at a Seikagaku...
AIM: To observe the effect of hyaluronic acid (HA) at different concentrations on the metabolism of cartilage matrix in the interleukin-1 β(IL-1β) and chondral synovium co-culture model, so as to explore the possible mechanisms of viscosupplementation to treat osteoarthritis. METHODS: The expe...
Osteoarthritis (OA) leads to significant pain and disability. For pain relief, a tailored approach using non-pharmacological and pharmacological therapies is recommended. If adequate symptom relief is not achieved with acetaminophen, other pharmacological options include non-steroidal anti-inflammatory drugs ...
17 In optimal conditions (pH 6.5 to 10.5), purified streptococcal HAS could polymerize HA at a rate of approximately 240 monosaccharides/second.18 This high synthesis rate raises the point that the cytosolic availability of uridine diphosphoglucuronic acid (UDP-GlcA) and uridine diphosphate N-...
The role of collagen in cancer: from bench to bedside. J. Transl. Med. 17, 309 (2019). Google Scholar Poole, A. R. et al. Type II collagen degradation and its regulation in articular cartilage in osteoarthritis. Ann. Rheum. Dis. 61, ii78–ii81 (2002). CAS Google Scholar Land...
Chemokines are an indispensable component of our immune system through the regulation of directional migration and activation of leukocytes. CXCL8 is the most potent human neutrophil-attracting chemokine and plays crucial roles in the response to infecti
FGF = fibroblast growth factor; FGFR = fibroblast growth factor receptor; H&E = hematoxylin and eosin; IL = interleukin; MIA = monoiodoacetic acid; MMP = matrix metalloproteinase; OA = osteoarthritis; PBS = phosphate-buffered saline; PGE2 = prostaglandin E2; S-GAG = sulfated glycosaminoglycan....
The action of hyaluronic acid is the increase of the joint cartilage com- ponents synthesis and the reduction of degradation. It also induces an analgesic effect by the inhibition of inflammation and pain receptors [1]. Results The results we could evaluate till now are good as concerning pain...
The animal model deals with the species other than the human, as it can imitate the disease progression, its’ diagnosis as well as a treatment similar to human. Discovery of a drug and/or component, equipment, their toxicological studies, dose, side eff
Biomarkers of Osteoarthritis Osteoarthritis (OA) is a painful disorder of joints characterized by destruction of articular cartilage and remodeling of bone. At the molecular level, loss of the cartilage proteoglycan is clearly evident at a relatively early stage followed by erosion and degradation of ...