Department of Neurosurgey Johns Hopkins University School of Medicine Baltimore, MD;David A. WilsonDepartment of Neurosurgey Johns Hopkins University School of Medicine Baltimore, MD;Marco FerrariDepartment of Neurosurgey Johns Hopkins University School of Medicine Baltimore, MD;Klaus Cross...
Iron controls the richness and maturation of erythroid precursors, in relation to the need for oxygen in the human body. When iron transport is insufficient to meet oxygen demand, erythrocyte production decreases. Iron is also a constituent of myoglobin in muscle tissues; it plays a vital role ...
A secondary system for the clearance of hemoglobin has been described, wherein hemoglobin binds to haptoglobin and is subsequently recognized by CD91 expressed on macrophages, facilitating its clearance [99]. The splenic marginal zone is characterized by an abundance of B cells and specialized ...
The role of red cell 2, 3-DPG and adult hemoglobin. Ped Res 1971; 5: 235–245.Delivoria-Papadopoulos, M, Ronceric, NP, Oski, FA (1971) Postnatal changes in oxygen transport of premature and sick infants: the role of red cell 2,3 diphosphoglycerate and adult hemoglobin. Pediatr Res ...
where Hb = hemoglobin concentration, g/dl; SaO2= arterial oxygen saturation, %; CO = cardiac output, 1/min.\mathop \text{V}\limits^\text{.}\mathop \text{V}\limits^\text{.}O2can either be calculated indirectly, Hb x (SaO2— SvO2) X CO X 0.134, where SvO2= venous oxygen saturation...
Ferroptosis, a recently identified form of cell death initially proposed by Dixon et al. in 2012 [14], is an iron-dependent form of cell death characterized by the accumulation of lipid reactive oxygen species (ROS) [15]. Unlike the formation of autophagosome in autophagy or nuclear fragmentati...
Although haemoglobin is a known carrier of oxygen in erythrocytes that functions to transport oxygen over a long range, its physiological roles outside erythrocytes are largely elusive1,2. Here we found that chondrocytes produced massive amounts of haemoglobin to form eosin-positive bodies in their ...
(HIFs), which become stable under low oxygen conditions. VEGF-A binds to its receptors VEGFR1 (Flt1) and VEGFR2 (Flk1 or KDR) on the cell membrane of ECs, and activates downstream signaling pathways, including PI3K/AKT, Ras/MAPK, FAK/Paxillin, and PLCγ pathways, to regulate cell ...
Osteogenesis is critical for the maintenance of a healthy and fully functional skeletal system, which is tightly coupled to the normal growth of blood vessels during endochondral bone formation9,10,11. Blood vessels mediated the transport of circulating cells, oxygen, nutrients and waste products and...
,3-DPG 的作用是Role of 2,3-DPG in hemoglobin:A.向组织释放氧Unloading oxygen to tissuesB.增加与氧的亲和