Glucagon appears to be a true hormone with a major function in blood glucose regulation, Roger H. Unger, MD, of Dallas, told the fifth congress of the International Diabetes Federation. Unger said that glucagon apparently is secreted by the pancreas during times of glucose need. Its primary ...
Role of glucagon in regulation of glucose production in exercising dogs Eleven dogs ran on a treadmill for 3 h. Within the 1st h, exercise doubled plasma immunoreactive glucagon (IRG), glucose production (Ra) and lactate, but i... BJ Issekutz,M Vranic - 《American Journal of Physiology》...
The overwhelming increase in the prevalence of overweight and obesity in recent years represents one of the greatest threats to the health of the developed world. Among current treatments, however, gastrointestinal (GI) surgery remains the only approach
Akira,Niijima - 《Journal of the Autonomic Nervous System》 被引量: 257发表: 1983年 Glucose sensitive afferent nerve fibers in the liver and regulation of blood glucose Niijima A (1980) Glucose sensitive afferent nerve fibers in the liver and regulation of blood glucose. Brain Res Bull 5 [...
Bone mainly functions as a supportive framework for the whole body and is the major regulator of calcium homeostasis and hematopoietic function. Recently, an increasing number of studies have characterized the significance of bone as an endocrine organ,
Using Type 2 diabetic mice models, the researchers investigated the metabolic effects of the drug REMD 2.59, a human antibody and competitive glucagon receptor antagonist. The antibody improved glucose levels in the blood and enhanced insulin action in liver and skeletal muscle. Also, nondiabetic mic...
The regulation of glucagon secretion from pancreatic α-cells is fundamental to the maintenance of glucose homeostasis; under normal conditions they secrete glucagon in response to starvation-induced hypoglycemia. Glucagon is a 29-amino acid peptide hormone that elevates blood glucose concentration by gly...
How small concentrations of portal glucose initiate the nervous signal is still unclear. Early 2000s, Burcelin et al. showed that in fasted mice, the response to a flux equivalent to EGP requires the presence of GLUT2 [20] and an active glucagon-like peptide 1 (GLP1) receptor [21]. The...
Role of the gut–brain axis in energy and glucose metabolism Article Open access 26 April 2022 Metabolic Messengers: glucagon-like peptide 1 Article 11 January 2021 The metabolic impact of small intestinal nutrient sensing Article Open access 10 February 2021 References Tanday, N., Flatt,...
TXNIP expression has been strongly associated with glucose-sensing transcriptional complexes, especially the ChREBP/MondoA:Mlx complex [33]. As a result, MondoA/TXNIP signaling has been linked to the regulation of cellular glucose [34]. The factors involved in TXNIP regulation (Table2) constitute...