The Lysosomal Concept: Role in Connective Tissue DiseaseW. B. ChodirkerCanadian Rheumatism Association
Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis. Breast cancer almost invariably metastasizes to bone in patients with advanced disease and causes local osteolysis. Much of the morbidity of advanced breas... TA Guise,...
They also noted that decreasing this gene's expression in cardiac connective tissue significantly decreased cardiac fibroblast proliferation and downregulated the IL1RL1 gene. This gene encodes one of the most important heart failure biomarkers, sST2. High levels of this biomarker are associated with f...
Connective tissue growth factor (CTGF), a profibrotic cytokine, plays a key role in this deleterious process. Some beneficial effects of IGF1 on ... M Touvron,B Escoubet,M Mericskay,... - 《Disease Models & Mechanisms》 被引量: 69发表: 2012年 Plasma CCN2/connective tissue growth factor...
3), and the commonly used methods for establishing skin disease-related stress models are presented in Box 1. Box 1 Specific details of stress models of skin diseases. Chronic restraint stress (CRS) Chronic restraint stress is achieved by confining the mice in a restraint bucket for a certain...
Cardiovascular disease (CVD) is the leading cause of death, globally, and its prevalence is only expected to rise due to the increasing incidence of co-morbidities such as obesity and diabetes. Medical treatment of CVD is directed primarily at slowing or reversing the underlying atherosclerotic proc...
Multiple medical and surgical treatments have been described in the early stages of Avascular Necrosis (AVN) of the femoral head which delay the disease progression. Similarly, multiple studies, trials, reviews, and systematic reviews exist for the various treatments described and their outcomes but ...
Connective tissue growth factor (CTGF) belongs to the CCN family of immediate early response genes. Several lines of evidence suggest that CTGF is an important pro-fibrotic molecule in renal disease and that CTGF contributes to TGF-beta bioactivity in this setting. CTGF expression is increased in...
how to better treat tendon-bone injury, alleviate the clinical symptoms of patients, and delay the progression of the disease have become problems in the field of orthopedics [10]. With the development of tissue engineering technology, stem cells for tendon-bone injury treatment methods have achiev...
In patients with IMIDs, platelets are activated by disease-specific factors, and their activation often reflects disease activity. Here we summarize the evidence showing that activated platelets have an active role in the pathogenesis and the progression of IMIDs. Activated platelets produce soluble ...