In order to determine if cholesterol is involved in PRRSV infection in MARC-145 cells, we used three pharmacological agents: methyl-尾 cyclodextrin (M尾CD), mevinolin, and filipin complex to deplete cholesterol in MARC-145. Although these agents act by different mechanisms, they all ...
A major cellular source of IFN-Is and IFN-IIIs is plasmacytoid dendritic cells (pDCs) (Fig.1), particularly during systemic viral infections and certain autoimmune diseases characterized by high expression of ISGs called interferonopathies [1]. However, following infection by a virus, virtually any...
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Nanomedicine has already proven its value through its application of drug delivery and nanosensors in other diseases [9,10,11]. In this review, we are going to discuss nanomedicine options for COVID-19 management. To do so, we will first examine the pathology of COVID-19 to set a foundati...
To study their interactions amongst each other and with a cellular receptor for PRRSV, CD163, I cloned each of the viral glycoproteins and CD163 in various expression vectors. My studies have shown that while the GP2a, GP3, and GP4 are co-translationally glycosylated, the GP5 is post-...
CD163; soluble CD163; sCD163; endothelial cells; physiology; cancer1. Introduction Macrophages are important regulators of homeostasis, in physiological and pathological conditions. They contribute to tissue morphogenesis and repair, regulating inflammatory processes, and can be found either in the ...
These antibodies are directed to a range of host proteins, including immunoglobulins [163], cardiolipin [164], and members of the soluble innate immune proteins. Despite there being no evidence for CRP interactions with HCV, autoantibodies to CRP are produced in HCV infection, related to ...
(CPN). This study aimed to investigate the possible mechanisms underlying the amelioration of LPS-induced acute liver injury in piglets by CME or CPN supplementation using transcriptomic and metabolomic analyses. We found that CPN or CME supplementation significantly decreased the C-reactive protein ...