Y KatayamaK MurataSpringer-VerlagKybernetikKatayama, J., Murata, K. (1974) Role of microstructure of nerve impulse train: relation to transmission of neuronal activity and coding mechanisms of neuronal information. Cybernetics 16: pp. 119-126...
In “The Structure of Scientific Revolutions” (SSR; Kuhn1962), Thomas Kuhn outlined his view of how science was done, rather than how it should be done. The SSR introduced several terms, principally “paradigm” and “paradigm shift” that are used routinely by scientists. However, it is u...
The Role of CaMKIIb Upregulation in Schizophrenia: A New Drug Target for Schizophrenia Treatment Gabriela Novak*, Philip Seeman University of Toronto and CAMH, Toronto, ON, Canada Background: The cerebral frontal cortex of schizophrenia patients shows elevated levels of mRNA for calcium/calmodulin-...
which is paincaused by the normal activation ofneural pathways in response to a pain-initiatingstimulus. Hallmark characteristicsof neuropathic pain are loweringof the pain threshold andexcitation of the nerve pathways longafter the initial injury has healed. Thepain becomes chronic in nature,...
fire action potentials together and undergo increases in levels of intracellular calcium synchronously(81–83,89). On a larger spatial scale, the pattern of activity resembles a "wave" that travels across local regions of the retina at about 100-300 µm/s, and involves cells situated within ...
RESIDUAL CALCIUMDELAYED RELEASEEXOCYTOSISFROGTRANSMISSIONTo determine the role of presynaptic ryanodine receptors in the regulation of the kinetics of neurotransmitter quantum secretion caused by a nerve impulse in the experiments on the mouse neuromuscular junction, temporal parameters of phase synchronous and...
incomplete spinal cord injury; neuromodulation methods; nerve electrostimulation; repetitive transcranial magnetic stimulation; kinesiotherapy; electromyography1. Introduction Incomplete spinal cord injury (iSCI) handicaps neuronal impulse transmission between the supraspinal centres and muscles, leading to varying ...
Moreover, melatonin also suppresses the activation of calcium/calmodulin-dependent kinase II (CaMKII) in axons and promotes nerve regeneration [136]. It is interesting to note that the host CaMKII inhibition is a potential target to develop prophylactic antiviral drugs against Dengue (DENV) and ...
Intracellular trafficking plays a critical role in the functioning of highly polarized cells, such as neurons. Transport of mRNAs, proteins, and other molecules to synaptic terminals maintains contact between neurons and ensures the transmission of nerve impulses. Cytoplasmic polyadenylation element binding...
A recent study found increased TLR4 expression but observed no change in the expression of the transient receptor potential vanilloid type 1 (TRPV1) channel (an ion channel permeable to calcium ions) in microglia and astrocytes in the ventrobasal thalamic complex during neuropathic pain in mice. ...