The domain-sorting signal is in the region between amino acids 110202 of the NaV1.2 channel. The C-terminal 451 amino acids of NaV1.2 likely contain determinants that interact with neuron-specific factors to direct NaV1.2 to the axon.doi:10.4161/chan.3.3.8854...
Skip to main contentSkip to article
The presence of chronic inflammation has been reported in VCI patients during pre-clinical, clinical and severe stages of VaD [64,65,66,67]. These studies reported elevated levels of classic inflammatory mediators such as interleukin-1 beta (IL-1β), interleukin-6 (IL-6), TNFα and C-reac...
BACE1 and BACE2 belong to a class of proteases called β-secretases involved in ectodomain shedding of different transmembrane substrates. These enzymes have been extensively studied in Alzheimer's disease as they are responsible for the processing of AP
Taken together, our findings indicate that protrudin interacts with spastin and induces axon formation through its N-terminal domain. Moreover, protrudin and spastin may work together to play an indispensable role in motor axon outgrowth. J. Cell. Biochem. 113: 22962307, 2012. 2012 Wiley ...
Therefore, overexpression of FlnA has a tumor-promoting effect, only when it is localized to the cytoplasm, whereas if FlnA undergoes proteolysis and the resulting C-terminal fragment localizes to the nucleus, it acts to suppress tumor growth and inhibit metastasis. Development of drugs to target...
There are hundreds of different types of cells in our body, arranging from blood cells in vessels to multinucleated myotubes in muscles. For example, nervous system cells including tiny glial cells and meter-long neuron axon, varying widely in morphology and functions. All these cells work togeth...
axon guidance, synaptogenesis, and synaptic plasticity, positioning it as a plausible contributor to the pathophysiology of ASD and related disorders. In this study, we show that the Q857X mutation produced a truncated protein lacking forward signaling and that global disruption of oneEphB2allele (...
Mice with deletion of Ndufs2, the basic subunit of the MCI catalytic core in dopaminergic neurons, exhibit progressive, axon-first, and levodopa-responsive PD.83 Despite maintaining mitochondrial membrane potential and regular somatic mitochondrial density in dopaminergic neurons with conditional knockout...
Fig. 3: Schematic illustration of SST release in the presynaptic terminal of an SST+IN. In SST-expressing neurons, SST and GABA are known to be colocalized and coreleased. SST (yellow dots) and GABA (gray dots)-containing vesicles are first delivered to the presynaptic terminal and released...