In addition, circulating CCN4 level in obese pregnant women with GDM is positively correlated with numerous clinical metabolic parameters such as systolic blood pressure, fasting blood glucose and aspartate aminotransferase (AST), highlighting the crucial role of CCN4 in the pathophysiology of GDM [...
Mitochondria are intracellular organelles with double membranes and their own genome in eukaryotic cells [1]. In mammalian cells, the fundamental function of mitochondria is to supply energy by adenosine triphosphate (ATP) production through the tricarboxylic acid (TCA) cycle and oxidative phosphorylation...
Schousboe (1989) Role of aspartate aminotransferase and mitochondrial dicarboxylate transport for re- lease of endogenously and exogenously supplied neurotransmitter in glutamatergic neurons. Neurochem. Res. 14:359-366.Palaiologos, G., Hertz, L., Schousboe, A. (1989) Role of aspartate ...
CCN4 (cellular communication network factor 4), a highly conserved, secreted cysteine-rich matricellular protein is emerging as a key player in the development and progression of numerous disease pathologies, including cancer, fibrosis, metabolic and inflammatory disorders. Over the past two decades, e...
Plasma transaminases: alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were measured using standard procedures (ALT: GNV41125 and AST: GNV40125 from RAL, Barcelona, Spain). Total bilirubin, insulin, and sFlt1 were measured in plasma using immunosorbent commercial assay kits (total ...
Plasma samples from mice were diluted in ddH2O and triglycerides, cholesterol, HDL, LDL, alkaline phosphatase (ALP), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were analyzed in the Pathophysiology core facility of the MDC, Berlin, with an AU480 Chemistry Analyzer (Be...
In addition to inflammatory markers, other bio-humoral elements such as lactic dehydrogenase (LDH), alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatinine, bilirubin, procalcitonin, D-dimer have been identified for their ability to discriminate COVID-19 patients with poor prognosis...
Abnormalities of liver functions have been reported in COVID-19 infected patients [32]. The levels of Alanine aminotransferase (ALT), Aspartate transaminase (AST), bilirubin, and Lactate dehydrogenase (LDH) were significantly elevated in severe cases compared with milder cases [33,34,35,36,37,38...
other immunosuppressants, inhibition of new blisters, reduction in pruritus, and reduction in eosinophil counts [63]. One patient experienced epigastric pain and a mild elevation of liver enzymes (aspartate aminotransferase—41, alanine aminotransferase—63), which resolved with treatment [63]. Another...
Specifically, 36-week-old and 48-week-old female mice, equivalent to 38–40 and 48–50 years of age in humans, received oral quercetin for 1 month (Fig. 8e). The quercetin-treated group showed regular weight (Extended Data Fig. 10a) and organ function (Extended Data Fig. 10b–g), ...