Journal of Medical SciencesEL-Batouty MF, EL-Lakkany A, Hawas S, EL-Nashar E, Hafez MM, EL-Desoky T, et al. Role of articular cartilage and chondrocyte changes and mononuclear apoptosis in the pathogenesis and strategy of therapy in polyarticular juvenile rheumatoid arthri- tis. J Med ...
Articular cartilage, a smooth and wear-resistant tissue covering the surface of joints, supports and distributes applied loads. It is characterized by viscoelastic, anisotropic, tension–compression, and nonlinear properties, endowing cartilage with the ability to withstand extremely high mechanical stress...
Articular cartilage, tissue engineering, regeneration, repair, scaffolds, cells, stem cells, self-assembly, bioactive factors, regulatory affairsArticular cartilage repair and regeneration continue to be largely intractable due to the poor regenerative properties of this tissue. The field of articular ...
Introduction The aetiology of osteoarthritis (OA) is unknown although abnormal loading of the joint is a contributory factor. We have demonstrated previously that a cyclic, compressive load (0.5MPa, 1Hz) applied to immature articular cartilage induces a significant increase in the expression and ...
The increased HIF-1α and HIF-2α mediate the response of chondrocytes to hypoxia. HIF-1α regulates chondrogenesis by regulating SOX9 expression in the genetic level, HIF-1 also serves to regulate both autophagy and apoptosis. Therefore, HIF-1α may protect articular cartilage by promoting the...
A. Collagens of articular cartilage: structure, function, and importance in tissue engineering. Crit. Rev. Biomed. Eng. 35, 363–411 (2007). Google Scholar Lin, K. et al. Advanced collagen-based biomaterials for regenerative biomedicine. Adv. Funct. Mater. 29, 1804943 (2019). Google ...
The role of bone has not been fully elucidated, but changes in bone seem to be secondary to alterations in articular cartilage, which change the mechanical environment of the bone cells and induce them, in turn, to modulate tissue structure....
Erosion of articular cartilage and subchondral bone, ligaments, and tendon tissue leads to the destruction of articular cartilage, dissolution of subchondral bone, and joint injury (joint dislocation, joint fusion, and ossification). The S100 protein family is also involved in the pannus formation in...
The role of bone has not been fully elucidated, but changes in bone seem to be secondary to alterations in articular cartilage, which change the mechanical environment of the bone cells and induce them, in turn, to modulate tissue structure. 展开 ...
The articular hyaline cartilage of synovial joints has a very limited capacity for repair after injury. In contrast, the mandibular condylar cartilage of the temporomandibular joint possesses as intrinsic potential for regeneration. This study aimed to test the hypothesis that cultured allografts of mandi...