Biochemistry The role of conserved small protein B amino acids in trans-translation STATE UNIVERSITY OF NEW YORK AT STONY BROOK DulebohnDaniel PatrickBacteria possess a unique salvage mechanism for rescuing ribosomes stalled on aberrant mRNAs. This salvage mechanism, termed -translation, is mediated ...
However, before translation, aminoacylated tRNAs are produced by aminoacyl tRNA synthetases (aaRSs), these enzymes are responsible for catalyzing correct attachment of amino acids to tRNAs, and are able to recognize and discriminate among the pool of different amino acids and tRNAs inside the cell....
In an amino acid-rich environment TOR is active and regulates protein translation but also inhibits macroautophagy (hereafter referred to as autophagy). When extracellular amino acids are limiting, autophagy recycles intracellular constituents as a way to provide an alternative source of amino acids (...
mapping 64 three-letter codons to 20 amino acids and three stop codons, is highly conserved. This conservation has evolved to minimize the effects of genetic mutations and translational decoding errors, thus providing optimal robustness in the flow of the genetic information1. Moreover, the universa...
Our data identify a molecular function of the C38 methylation introduced by Dnmt2 that can be directly connected to a physiological function, which lies in a system-wide novel post-transcriptional regulation mechanism. Homopolymeric stretches of amino acids other than poly-Asp are widespread in the...
We found 40 genes associated with viral susceptibility and 21 of them were associated with severe SARS-CoV disease and severe COVID-19. Some of those genes were implicated in TLR pathways, others in C-lectin pathways, and others were related to inflammasome activation (cytokine storm). Conclusio...
of some anticancer drugs. In addition, miR-1-3p also plays a role in tumor diagnosis and prognosis. In the future, the function and mechanism of miR-1-3p still need to be further investigated, which will be beneficial to provide a solid theoretical foundation for clinical translation. ...
Peptides with a minimum length of 6 amino acids and up to two missed cleavages were included. Cysteine carbamidomethylation and methionine oxidation were specified as fixed and variable modifications, respectively. The acceptable FDR was set to 1% at the peptide, protein, and modification levels. ...
Ubiquitination is the connection of ubiquitin, a molecule consisted with 76-amino acid, with the substrate protein or itself in covalent form via its C-terminus [3]. According to the number of connected ubiquitin molecules, ubiquitination can be classified into mono-ubiquitination (modified by a ...
The last 4 amino acids of α-tubulin C-terminal tail are represented. Tubulin carboxypeptidases (TCPs, VASH1 or VASH2 associated with SVBP) removes the C-terminal tyrosine residue (Y, in magenta) of α-tubulin to generate detyrosinated tubulin. Detyrosinated tubulin can be re-tyrosinated...