Of interest, recent work has focused on the role of alternative splicing in prostate cancer and prostate cancer health disparities. We will provide a review of prostate cancer health disparities involving the African American population, alternative RNA splicing, and alternative splicing in prostate ...
Chapter 280–The Role of Alternative Splicing During the Cell Cycle and Programmed Cell DeathThis chapter summarizes some of the progress made in the past years on pre-mRNA splicing regulation, focusing on genes involved in programmed cell death (apoptosis) and cell cycle control. Alternative ...
While high-throughput sequencing has provided insights into its mechanisms, the role of alternative splicing (AS) in SS remains underexplored.#To investigate the relationship between immune infiltration in the salivary glands and AS events at the transcriptomic level, and to identify potential biomarkers...
Alternative splicing regulation has recently emerged as a significant mechanism in cancer development and progression. While it has been established that many chemotherapeutic drugs affect alternative splicing (reviewed in [2]), the role of alternative splicing in drug resistance is much less understood....
valine isoforms of RBM10v1 and RBM10v2 result from alternative splicing. Protein modeling of the RNA Recognition Motif (RRM) within which the alteration occurs, shows that the presence of valine inhibits the formation of one of the two ??-helices associated with RRM tertiary structure, whereas...
A large number of splicing proteins associated with SNAIL, including SRSF1, a regulator of alternative splicing. Co-immunofluorescence and co-immunoprecipitation data from our lab indicate that SNAIL associates with splicing protein SRSF1. Further, SNAIL co-immunoprecipitated with SRSF1 in the presence...
In addition to transcriptional regulation, post-transcriptional regulation, including phosphorylation and ubiquitination, has an important part in controlling the expression levels of many antiviral immune-related genes27–32. The alternative splicing of central genes involved in antiviral pathways, such as ...
(a common pattern of alternative splicing) in theP5CDHgene that predicts poorer survival in rectal cancer patients128, although the physiological implications of this alternative splicing event are unknown. Overall, the contribution ofP5CDHto tumor progression is likely to be limited, asP5CDHhas not...
Alternative pre-mRNA splicing is a critical mechanism that generates multiple mRNA from a single gene, thereby increasing the diversity of the proteome. Recent research has highlighted the significance of specific splicing isoforms in cellular processes, particularly in regulating cell numbers. In this ...
[28,29]. In addition, certain snoRNAs can also target and regulate mRNAs. For certain orphan C/D box snoRNAs, it has been shown that they can target mRNAs and guide mRNA methylation, direct 3’-end processing, alternative splicing, and mRNA stability [30,31]. Of relevance, several ...