Elongation factor-catalyzed GTP hydrolysis is a key reaction during the ribosomal elongation cycle. Recent crystal structures of G proteins, such as elongation factor G (EF-G) bound to the ribosome, as well as many biochemical studies, provide evidence that the direct interaction of translational ...
What is the role of the ribosome?Proteins:Proteins have many functions within the body. They can act as cellular transporters, enzymes, structural features, as energy sources, and motor molecules. Proteins are produced via translation by combining amino acids together via peptide linkages....
Our data suggest that the ribosome-bound mRNA may take a secondary structure around the junction sequence. For in vitro studies, we used mRNA that incorporated different radioactively labeled amino acids based on the frameshift at the junction sequence, UAAUG, of two translationally coupled ORFs. ...
However, RRF is essential for correct ribosomal recognition of the AUG codon as the initiation site for the lysis gene.Inokuchi YHirashima ASekine YJanosi LKaji AEMBO JournalInokuchi, Y., Hirashima, A., Sekine, Y., Janosi, L. and Kaji, A. (2000) Role of ribosome recycling factor (RRF...
Ribosome, particle that is present in large numbers in all living cells and serves as the site of protein synthesis. Ribosomes occur both as free particles in prokaryotic and eukaryotic cells and as particles attached to the membranes of the endoplasmic
Formation of a functional ribosome-membrane junction during protein translocation requires the participation of a GTP-binding protein J. Cell Biol., 103 (1986), pp. 2253-2261 View in ScopusGoogle Scholar 5 T Connolly, R Gilmore The signal recognition particle receptor mediates the GTP-dependent di...
Ribosomes' function is to manufacture proteins. They do this in a process known astranslation, which involves taking instructions encoded in messenger ribonucleic acid (mRNA) and using these to assemble proteins fromamino acids. Overview of Cells ...
Analyzes the role of ribosome-translocon complex in translation and assembly of polytopic membrane proteins. Essential function of polytopic membrane prot... Bibi,Eitan - 《Trends in Biochemical Sciences》 被引量: 0发表: 1998年 Both lumenal and cytosolic gating of the aqueous ER translocon pore are...
Protein synthesis, one of nature's most fundamental processes within all living cells, is catalyzed by the ribosome, a highly conserved, massive, two-subunit ribonucleoprotein complex. Ribosomes synthesize proteins based on the sequence of triplet-nucleotide codons presented by the messenger RNA (mRNA...
MicroRNAs (miRNAs) are small noncoding RNAs that regulate posttranscriptional genes by either blocking translation of mRNAs by ribosomes or by promoting their degradation [83,84]. It has been previously shown that the miRNA, miR-182, is involved in repressing BRCA1 protein levels. Blocking the ...