Utilising both pharmacological and CRISPR/Cas9 gene editing based approaches, we identified ROCK1 but not PAK2 or LIMK1 as a key non-redundant positive regulator of apoptotic membrane blebbing as well as ApoBD
产品活性:ROCK1 蛋白是调节肌动蛋白细胞骨架、细胞极性、平滑肌收缩和多种细胞功能的关键激酶。它通过磷酸化 DAPK3、GFAP、LIMK1、LIMK2、MYL9/MLC2、TPPP、PFN1 和 PPP1R12A 等底物来控制应力纤维、粘着斑形成、神经突回缩和细胞运动。ROCK1 蛋白, Human (Sf9) 是重组的 ROCK1 蛋白,由 Sf9 insect cells ...