Here, we accomplish this objective using activity-based protein profiling coupled with quantitative MS to globally map the targets, both specific and nonspecific, of covalent kinase inhibitors in human cells. Many of the specific off-targets represent nonkinase proteins that, notably, have conserved ...
Lanning BR, Whitby LR, Dix MM, Douhan J, Gilbert AM, Hett EC, Johnson TO, Joslyn C, Kath JC, Niessen S, Roberts LR, Schnute ME, Wang C, et al. A road map to evaluate the proteome-wide selectivity of covalent kinase inhibitors. Nat Chem Biol. 2014; 10:760-767....
On the road"traveling" is from 1640s.Road test(n.) of a vehicle's performance is by 1906; as a verb from 1937.Road hog"one who is objectionable on the road" [OED] is attested from 1886;road rageis by 1988.Road mapis from 1786;road tripis by 1950, originally of baseball teams....
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Antimicrobial susceptibility testing (AST) technologies help to accelerate the initiation of targeted antimicrobial therapy for patients with infections and could potentially extend the lifespan of current narrow-spectrum antimicrobials. Although concept
How much is the train fare to Belvedere Avenue at Kapanui Road (Near 101)? The train fare to Belvedere Avenue at Kapanui Road (Near 101) costs about $2.00 - $6.50. See Belvedere Avenue at Kapanui Road (Near 101) stop, Wellington, on the map Public transport to Belvedere ...
to Whitby. The Coastliner also runs to Yorkshire's Food Capital Malton, then on to York. Sealife nearby, and Flamingoland is also within easy reach. The open theatre which hosts musical events is within walking distance. The property is perfect for families,sports guests,nature lovers,bird...
R. et al. A road map to evaluate the proteome-wide selectivity of covalent kinase inhibitors. Nat. Chem. Biol. 10, 760–767 (2014). This paper describes pull-down proteomics inhibitor profiling methods for assessing the proteome-wide selectivity of covalent inhibitors. CAS PubMed PubMed ...
Anywhere in “Zone 1” of the London Underground map would be a good bet. See our post on where to stay in London for your first time. What are the most popular sights in London? There are many, but some of the top ones include the London Eye, the Tower of London, Buckingham ...
purchased tickets. Older children can use the “treasure map” to guide their visit to York Minster. The map has nine symbols scattered across an illustration of the inside of the cathedral. Children can find everything from a dragon to the 750-year old Five Sisters window using the map. ...