Ro5-4864 also suppressed cell proliferation, as well as adenosine triphosphate and lactate production, during T cell activation. Moreover, the inhibitory effects of Ro5-4864 on T cell responses were conserved in TSPO-deficient cells. Our results suggest that Ro5-4864 inhibits CH responses by ...
Ro5-4864 is a selective agonist at TSPO, whereas clonazepam is a selective agonist at the GABAA receptor. Ro5-4864 suppressed pro-inflammatory MC effector functions in response to antigen (Ag) (degranulation/cytokine production) and LPS and SCF (cytokine production), whereas clonazepam was ...
既往研究证实,TSPO与特异性配体结合后,能够促进神经类固醇生成、缓解神经性疼痛和减轻神经炎症反应,因此被认为是一种潜在的治疗靶点。Ro5-4864(7-chloro-5-4-Chlorophenyl-1,3-dihydro-1-methyl-2-H-1,4-benzod-iazepin-2)是苯二氮卓类药物的衍生物,已在多种神经毒性病理实验中证实可通过调节神经类固醇激素的...
Here, we investigated the involvement of TSPO/TSPO ligand in T cell responses using a 2,4-dinitro-1-fluorobenzene (DNFB)-induced contact hypersensitivity (CH) model. Treatment with Ro5-4864, a TSPO ligand, during DNFB sensitization reduced the number and activation status of CD4+ and CD8+ ...
The phosphorylation level of these proteins was found to be modulated by TSPO/PBR ligands, Ro 5-4864 and PK11195, in a range of concentrations from 0.01 to 1 渭M, in the same way as it was earlier described for brain mitochondria [Azarashvili et al., J Neurochem. , 2005]....
In this study, we investigated the archetypical TSPO specific ligand Ro5-4864 (10 mu M) effect in primary osteoblasts in culture aiming to further understand the TSPO role in these mature metabolically active cells.Rosenberg, NahumRosenberg, OritWeizman, AbrahamVeenman, LeoGavish, Moshe...
Ro5-4864 is a selective agonist at TSPO, whereas clonazepam is a selective agonist at the GABAA receptor. Ro5-4864 suppressed pro-inflammatory MC effector functions in response to antigen (Ag) (degranulation/cytokine production) and LPS and SCF (cytokine production), whereas clonazepam was ...
Ro5-4864 is a selective agonist at TSPO, whereas clonazepam is a selective agonist at the GABAA receptor. Ro5-4864 suppressed pro-inflammatory MC effector functions in response to antigen (Ag) (degranulation/cytokine production) and LPS and SCF (cytokine production), whereas clonazepam was ...
In vitro Effects of the Specific Mitochondrial TSPO Ligand Ro5 4864 in Cultured Human Osteoblasts.doi:10.1055/s-0043-103282Nahum RosenbergOrit RosenbergAbraham WeizmanLeo VeenmanMoshe GavishGeorg Thieme Verlag KG
结果:SAH可导致小鼠体重减轻,引起神经炎症反应及运动神经功能障碍.Ro5-4864缓解了SAH后小鼠体重的丢失,减少了脑组织含水量和降低了TNF-α的表达,一定程度地促进了神经功能恢复,但不能减少IL-1β的表达.结论:TSPO配体Ro5-4864具有一定的神经保护功能,可缓解小鼠SAH后体重下降和脑组织炎症因子升高水平,并改善小鼠神经...