计算RNASeq 的Power值 随着高通量测序技术的发展,RNA-Seq已经成为差异基因表达研究中的常规检测方法。RNA-Seq实验设计最重要内容之一就是选择最佳生物重复数以获得所需统计效能(sample size estimation,样本大小估计),或者估计在数据集中成功发现统计意义的可能性(power estimation,效能估计)。重复次数不足可能导致结论不可...
RNA-seq power computationTerry TherneauSteven Hart
RNA-Seq Power Simulation M Bimali,J Usset,BL Fridley 被引量: 0发表: 0年 Modeling of homogeneous reactive separation processes in packed columns The coupling of physical separation and chemical reactions in one unit operation, the so-called reactive separation processes (RSPs), are of increasing...
This is the source code for a RShiny App to provide power calculation for RNA-Seq experiments based on the RNASeqPower R package. It provides a graphical user interface that can be deployed online through any RShiny server. Deployed app can be found HEREAbout...
Power analysis is essential to optimize the design of RNA-seq experiments and to assess and compare the power to detect differentially expressed genes. PowsimR is a flexible tool to simulate and evaluate differential expression from bulk and especially s
RNA-Seq Power SimulationMilan BimaliJoseph UssetBrooke L. Fridley
RNA-SeqPowerWald testLikelihood ratio testSample size calculation and power estimation are essential components of experimental designs in biomedical research. It is very challenging to estimate power for RNA-Seq differential expression under complex experimental designs. Moreover, the dependency among ...
Statistics Statistical power for RNA-seq data to detect two epigenetic phenomena THE OHIO STATE UNIVERSITY Shili Lin ChenDao-PengEpigenetics is the study of heritable changes in gene expression or cellular phenotype caused by mechanisms other than changing the underlying DNA sequence. Two epigenetic ...
It is very challenging to estimate power in designing these RNA-Seq experiments as well as to do comparative analysis. Currently there is a need of developing statistical methods for sample size calculation and power estimation with correlated RNA-Seq data....
Here, we present RNAseqPS, an advanced online RNAseq power and sample size calculation tool based on the Poisson and negative binomial distributions. RNAseqPS was built using the Shiny package in R. It provides an interactive graphical user interface that allows the users to easily conduct ...