motif其实就是一段固定的氨基酸序列模式，具有一定的特殊功能。说白了就是人们总结出来的，绝大多数具有...
AB0072Recruitment of RNA Targets by Connexin 43 RNA-Binding Motifs: Novel Mechanisms of Cellular CommunicationBackground Connexins (Cxs) are integral membrane proteins that form plasma membrane channels, allowing cell-matrix and cell to cell communication. Initially described in joining excitable cells ...
RNA-binding proteins are key regulators of gene expression, yet only a small fraction have been functionally characterized. Here we report a systematic analysis of the RNA motifs recognized by RNA-binding proteins, encompassing 205 distinct genes from 24
A compendium of RNA-binding motifs for decoding gene regulation. Nature 499, 172–177 (2013). Article CAS PubMed PubMed Central Google Scholar Castello, A. et al. Identification of RNA-binding domains of RNA-binding proteins in cultured cells on a system-wide scale with RBDmap. Nat. ...
DNA methyltransferases and polycomb repressive complexes, which both lack sequence-specific DNA-binding motifs, are recruited by long non-coding RNA (lncRNA) to specific genomic sites to methylate DNA and chromatin. Increasing evidence indicates that many lncRNAs contain DNA-binding motifs that can ...
Regulation of gene expression at the post-transcriptional level is mainly achieved by proteins containing well-defined sequence motifs involved in RNA binding. The most widely spread motifs are the RNA recognition motif (RRM) and the K homology (KH) domain. In this article, we survey the complet...
Frasch, RNA recognition motifs involved in nuclear import of RNA- binding proteins. RNA Biol. 7(3): p. 339-44.Cassola A., Noe G. and Frasch A.C. (2010). RNA recognition motifs involved in nuclear import of RNA-binding proteins. RNA Biology; 7(3): 339-44....
complexes in in vivo configurations with possibly lower affinities. In contrast native RIP is expected to recover high affinity, more direct interactions between proteins encoded RNA binding motifs and candidate RNAs. For less well understood proteins and protein complexes often both approaches are used...
(Fig.4f). Considering that CDK6 or the CDK6-CCND1 complex does not have DNA-binding function, we expected that CDK6 binds to LRPPRC promoter indirectly17,18. For E2F1, sequence analysis revealed two conserved E2F1 protein-binding motifs in the promoter region ofLRPPRC(Fig.4g). ...
b, The most significantly enriched RNA binding motifs as identified by HOMER57 analysis of eCLIP signal of unexpected hits along with corresponding P value, as calculated by the HOMER algorithm using default settings. c, Stacked bar graph of differentially spliced events after shRNA-mediated ...