Some types of mRNA are specific for certain types of cells, which encode for the proteins that are needed for the function of that particular cell such as mRNA for hemoglobin is found in Red Blood Cells (RBCs). Figure: Prokaryotic and Eukaryotic Messenger RNA (mRNA). Image Source:ScienceDire...
There are two main types of RNA editing events: adenosine to inosine (A-to-I) editing, catalyzed by ADARs on double-stranded RNA or ADATs on tRNA, and cytosine to uridine (C-to-U) editing catalyzed by APOBECs. This article provides an overview of the structure, function, and ...
The X-ray structure of the Hth1307 tetramer reveals the minimal functional protein assembly in substrate-free form We sought to better understand the structure and function of Hth1307 using protein crystallography. From the lower molecular weight fraction of Hth1307 discussed above, we first determine...
S. Structure and function of long noncoding RNAs in epigenetic regulation. Nat. Struct. Mol. Biol. 20, 300–307 (2013). Article CAS PubMed Google Scholar Chodroff, R. A. et al. Long noncoding RNA genes: conservation of sequence and brain expression among diverse amniotes. Genome Biol....
A protein structural domain that binds DNA and RNA, and that is found most commonly in transcription factors. It consists of a helix–turn–helix structure of 60 amino acids. GAR domain A Gly- and Arg-rich motif that adopts a repeated β-turn structure. It is found most commonly in prote...
The in vivo folding of RNA structure is tightly associated with its function and largely dependent on the cellular context [1, 2]. Because of the complexity within living cells, RNA folding in vivo could be very different from that in vitro [3, 4]. For many complex RNA structures, althoug...
telomerase (Gilley & Blackburn, 1999), and in viral genomic RNAs (for a review, see ten Dam et al., 1992). An RNA pseudoknot is a structural element of RNA which forms when nucleotides within one of the four types of single-stranded loops in a secondary structure (hairpin loop, bulge ...
Deriving a combined objective function in terms of probability theory seems more straightforward. One can find a consensus structure with maximum posterior probability by finding the structure that maximizes the joint probability of both the sequences and the structure. A fully probabilistic treatment of...
and incorporated these constraints into an algorithm for aligning RNAs with pseudoknots. Wong et al. [29] identified the pseudoknot type of a given structure and developed dynamic programming algorithms for structural alignments of different pseudoknot types. Huang et al. [4] applied a tree decomposi...
RNAs can also form complexes with molecules known asribonucleoproteins (RNPs). The RNA portion of at least one cellular RNP has been shown to act as a biologicalcatalyst, a function previously ascribed only to proteins. Types and functions of RNA ...