RNA-amino acid interactionstranslationThe cover picture shows the NMR structure of the Tat aptamer RNA (the ribose–phosphate backbone of the RNA is shown as a blue ribbon representation) in complex with two argininamide molecules (upper right) and details of the RNA–amino acid interactions (...
[9] Housman G, Ulitsky I. Methods for distinguishing between proteincoding and long noncoding RNAs and the elusive biological purposeof translation of long noncoding RNAs[J]. Biochim Biophys Acta,2016, 1859(1): 31-40. [...
They serve as a link between the nucleotide coding sequence of a mRNA molecule and the amino acid sequence of a polypeptide chain during the translation process [18,20,35]. To produce tRNAs, the respective genes are transcribed by RNA polymerase III (RNA Pol III) into precurso...
Translation of an mRNA molecule by the ribosome occurs in three stages: initiation, elongation, and termination. During initiation, the small ribosomal subunit binds to the start of the mRNA sequence. Then a transfer RNA (tRNA) molecule carrying the amino acid methionine binds to what is called...
运送氨基酸到对应 mRNA 密码子上的小 RNA(provide the amino acid corresponding相符 to each other) (3)核糖体 RNA(ribosomal RNA) 核糖体组成元件(a major component of the ribosome that provides the environment for protein systhsis) 在大肠杆菌中,rRNA量占细胞总RNA量的75%～85%,而tRNA占15%,mRNA仅占...
【2】Protein synthesis is referred to the process of producingnew peptide moleculesand then joining them together to produce proteins by coding genes into mRNA and then translating it. 蛋白质合成是指产生新的肽分子,然后将...
UAP56 is an important factor in the TREX complex, which is responsible for mRNA export. Here the authors show that the closely related RNA helicases, UAP56 and URH49, exhibit different three-dimensional structures due to one amino acid change. Accordingly, they form distinct apo-complexes and...
The biological process of RNA translation is fundamental to cellular life and has wide-ranging implications for human disease. Accurate delineation of RNA translation variation represents a significant challenge due to the complexity of the process and technical limitations. Here, we introduce RiboTIE, ...
Fidelity of translation The frequency in incorporating wrong amino acids into a protein is around 1:10 000. Messenger RNA Thegeneticmessage according to which proteins are synthesized on the ribosome. Peptidyl transfer The transfer of the peptide from the tRNA in the P-site to the amino acid o...
▲transfer RNA (tRNA)– It is used to transfer specific amino acids togrowing polypeptide chainsat the ribosomal site of protein synthesis during translation. 转移RNA(tRNA)–用于在翻译过程中将特定氨基酸转移到蛋白质合成的核糖体位点的生长...