1.RNA splicing dysregulation and the hallmarks of cancer. Nat Rev Cancer.2023 Jan 10
Moreover, cancer cells are capable of hijacking the expression of RNA-binding proteins (RBPs), leading to dysfunctional gene splicing and tumor-specific dependencies. Advances in next-generation RNA sequencing have revealed tumor-specific isoforms associated with these alterations, including the presence...
1.RNA splicing dysregulation and the hallmarks of cancer. Nat Rev Cancer.2023 Jan 10
1.RNA splicing dysregulation and the hallmarks of cancer. Nat Rev Cancer.2023 Jan 10 在抗体圈微信公众号回复“JPM23”可下载60家药企PPT合集。 识别微信二维码,添加抗体圈小编,符合条件者即可加入抗体圈微信群! 请注明:姓名+研究方向! 本公众号所有转载文章系出于传递更多信息之目...
2023年1月10日,来自美国弗雷德哈钦森癌症中心的Robert K. Bradley教授课题组在Nat RevCancer(IF:69.8)杂志上发表题为“RNA splicing dysregulation and the hallmarks of cancer”的文章[1]。在本文中,作者综述了肿瘤细胞转录组的剪接改变特征,异常剪接在肿...
因此,对普遍存在的癌症特异性剪接失调的深入研究,将为我们揭示这种剪接失调的机制起源和功能的新见解,并指导我们开发通过调节RNA剪接起作用的新型癌症治疗方法。 参考文献: 1.RNA splicing dysregulation and the hallmarks of cancer. Nat Rev Cancer.2023 Jan 10...
据RNA World国际论坛组委会获悉,来自美国Baylor医学院的Cheng Chonghui教授确认参与并将做主题报告。报告题目:Alternative RNA Splicing in Cancer 个…
Cancer-associated splicing alterations arise from both recurrent mutations and altered expression of-acting factors governing splicing catalysis and regulation. Cancer-associated splicing dysregulation can promote tumorigenesis via diverse mechanisms, contributing to increased cell proliferation, decreased apoptosis,...
10. A. Kahles, K. Van Lehmann, N. C. Toussaint, M. Hüser, S. G. Stark, T. Sachsenberg, O. Stegle, O. Kohlbacher, C. Sander; Cancer Genome Atlas Research Network, G. Rätsch, Compre- hensive analysis of alternative splicing across tumors from 8,705 patients.Cancer Cell34...
因此,对普遍存在的癌症特异性剪接失调的深入研究,将为我们揭示这种剪接失调的机制起源和功能的新见解,并指导我们开发通过调节RNA剪接起作用的新型癌症治疗方法。 参考文献: 1.RNA splicing dysregulation and the hallmarks of cancer. Nat Rev Cancer.2023 Jan 10...