Rgenta以独特方法和核心项目专注于挖掘传统意义上不可成药靶点的治疗潜力。参考资料：[1]Rgenta Therapeutics Announces Strategic Alliance with GSK to Develop RNA-Targeted Small Molecule Splice Modulators. Retrieved December 4, 2024, from https://www.prnewswire.com/news-releases/rgenta-therapeutics-announces-s...
2024年诺贝尔生理学或医学奖授予两位发现microRNA的科学家Victor Ambros和Gary Ruvkun。这次诺奖使学界的视线再次聚焦到microRNA。microRNA作为转录后调控的重要一环，研究其生理学功能、分子机制、对人类疾病研究和治疗有重要意义。本文聚焦免疫系统中microRNA的发现历史和最新进展，并尝试探讨该领域尚未解决的问题和发展方向...
We have developed a cell-based assay to monitor the activity of the RNAi pathway and find that the small-molecule enoxacin (Penetrex) enhances siRNA-mediated mRNA degradation and promotes the biogenesis of endogenous miRNAs. We show that this RNAi-enhancing activity depends on the trans-activation...
MicroRNA (miRNA) is a single-stranded small molecule RNA of non-coding proteins with a length of about 18-24 nucleotides in eukaryotic cells. It is widely found in multicellular organisms and viruses. The miRNA itself is not encoding protein which is mainly through the nucleic acid sequence co...
其中BV[38]可下调MACO/R大鼠中LncRNAH19的表达来减轻LncRNAH19对miR-181b-5p的海绵吸附作用,并下调miR-181b-5p的靶基因内皮细胞特异性分子1(endothelial cell-specific molecule 1,Esm1)的表达而减轻CIRI的炎症反应;电针(electroacupuncture,EA)[39]对MCAO/R大鼠进行电针治疗能下调LncRNA H19的表达,并通过1-...
目前已经获得成功应用的第三代测序技术主要有单分子实时测序技术(single molecule real time, SMRT)和纳米孔单分子测序技术(single-molecule nanopore DNA sequencing)。这类方法不需要PCR扩增,可以在单分子水平进行边合成边测序,通过直接检测原始状态的样本来获得核酸和核酸修饰的信息[105]。
[1] Rgenta Therapeutics Announces Strategic Alliance with GSK to Develop RNA-Targeted Small Molecule Splice Modulators. Retrieved December 4, 2024, from https://www.prnewswire.com/news-releases/rgenta-therapeutics-announces-strategic-alliance-with-gsk-to-develop-rna-targeted-small-molecule-splice-modulat...
被引量: 0发表: 2024年 Highly selective near-infrared fluorescent probe with large Stokes shift and sensitivity for H2S detection in water, foodstuff and imaging in living cells Hydrogen sulfide (H 2 S) is an endogenous gas signaling molecule that plays an indispensable role in human physiological...
Objective To explore the effects of epithelial cell adhesion molecule( EPCM) expression downregulation on the proliferation,invasion and drug sensitivity o... TU Xue-Song,HU Li-Xia,QU Guang-Qiao,... 被引量: 0发表: 2018年 Abstract 7194: Targeting AXL and MCL-1 to eradicate lazertinib toleran...
近日,中山大学药学院王红胜课题组在国际知名期刊Angewandte Chemie International Edition在线发表了题目为”Small molecule-inducible and photoactivatable cellular RNA N1-methyladenosine editing”的研究论文。该研究综合利用了CRISPR/dCas13b系统和化学诱导临近(Chemically Induced Proximity, CIP)技术,开发了一款能够靶向特定...