内容概要:The secret behind medicine that uses messenger RNA (or mRNA) is that it "teaches" our bodies how to fight diseases on our own, leading to groundbreaking treatments for COVID-19 and, potentially one day, cancer, the flu and other ailments that have haunted humanity for millennia. R...
G-quadruplexes (G4s) are secondary structures that can form in both DNA and RNA from guanine-rich sequences which are enriched in untranslated regions (UTRs). Here, Lee et al. find that putative G4-forming sequences are evolutionarily constrained, enriched for RNA-binding protein interactions...
Darwinian evolution depends on the selective propagation of heritable information. In biology that information is represented by the sequence of nucleotide subunits within an RNA or DNA genome and is expressed through the set of RNAs and proteins encoded by that genome. During the early history of ...
The most significant sections are genes, parts of DNA, which carry information about the amino acid sequence of proteins. Whereas DNA stores and duplicates genetic information, RNA plays a key role in its realization, that is, in the process of synthesis of a protein molecule in accordance ...
It is reported that RNA sequence of tumor-educated blood platelets (TEPs) can also become a blood-based cancer diagnosis method [90]. It should be noted that the lack of detailed functional implications of the identified RNAs in platelets in the field of platelet RNA research is also an ...
While much recent research has expanded our understanding of the molecular interactions between aphids and their host plants, it is lacking for the soybean aphid, Aphis glycines. Since its North American invasion, A. glycines has become one of the most d
In prebiotic evolution, self-replicating molecules are believed to have evolved into complex living systems by expanding their information and functions open-endedly. Theoretically, such evolutionary complexification could occur through successive appear
sequence (CDS) region of an mRNA, where an I is recognized as a G or a C as a U after deamination, it can lead to amino acid substitutions (called ‘recoding’) and enhance the diversity of the proteome. However, it is important to note that RNA editing is primarily carried out in...
Guanine-rich sequences are able to form complex RNA structures termed RNA G-quadruplexes in vitro. Because of their high stability, RNA G-quadruplexes are proposed to exist in vivo and are suggested to be associated with important biological relevance. However, there is a lack of direct eviden...
this binding of circPOLR2A to PKR could be blocked by a short 33-bp dsRNA of which binding doesn’t activates PKR, but the same short RNA in linear form had no effect. These observations led the investigators looking into the question whether the circRNAs could form intramolecular RNA duplex...