RNA sequencing, commonly referred to asRNA-seq, is a high throughput technique that allows researchers to determine the sequences and quantity of allRNAmolecules present is a sample—the “transcriptome.” RNA-seq can be used as a screen by comparing two or more samples to identify differences ...
RNA sequencesdo not just form a single structure; instead, they spawn an ensembleΦ(x) of secondary structures in which every structureθthat is compatible withx, i.e.,x∈C[θ], appears with relative frequencyp(x,θ)=exp(−g(x,θ)/RT)/Z, whereZ:=∑θexp(−g(x,θ)/RT)is ...
内容概要:The secret behind medicine that uses messenger RNA (or mRNA) is that it "teaches" our bodies how to fight diseases on our own, leading to groundbreaking treatments for COVID-19 and, potentially one day, cancer, the flu and other ailments that have haunted humanity for millennia. R...
G-quadruplexes (G4s) are secondary structures that can form in both DNA and RNA from guanine-rich sequences which are enriched in untranslated regions (UTRs). Here, Lee et al. find that putative G4-forming sequences are evolutionarily constrained, enriched for RNA-binding protein interactions...
It is reported that RNA sequence of tumor-educated blood platelets (TEPs) can also become a blood-based cancer diagnosis method [90]. It should be noted that the lack of detailed functional implications of the identified RNAs in platelets in the field of platelet RNA research is also an ...
et al. RNA-mediated epigenetic programming of a genome-rearrangement pathway. Nature 451, 153–158 (2008). CAS PubMed Google Scholar Ono, R. et al. Double strand break repair by capture of retrotransposon sequences and reverse-transcribed spliced mRNA sequences in mouse zygotes. Sci. Rep....
The upstream region of the catalytic domain contains two to three dsRNA-binding domains (dsRBDs), indicating that the binding of ADARs to RNA is not specific to a particular sequence, but rather to the structure dsRNA (Fig. 1B). The p110 isoform of ADAR1 is constitutively expressed in ...
The discovery of functional non-coding RNA sequences has led to an increasing interest in algorithms related to RNA analysis. Traditional sequence alignment algorithms, however, fail at computing reliable alignments of low-homology RNA sequences. The spa
While much recent research has expanded our understanding of the molecular interactions between aphids and their host plants, it is lacking for the soybean aphid, Aphis glycines. Since its North American invasion, A. glycines has become one of the most d
Dis3L2D391N–hairpinA–GCU14complex revealed that Dis3L2 maintains the same vase conformation as is observed in the RNA-free form (Fig.2band Extended Data Fig.2). However, the double-helical stem of the RNA was not resolved, suggesting that double-stranded RNA (dsRNA) is not stably ...