Virus particles are disparate in size, shape and composition, and enclose an RNA genome that can be either single stranded, double stranded, nonsegmented or segmented. Application of deep sequencing methodologies has unveiled their great abundance and ubiquity. The structural diversity of viral RNA ...
Global View of RNA-RNA Interactions RIC-seq捕获近百万条RNA-RNA interactions,其中大部分是mRNA-mRNA interactions,ncRNA-ncRNA interactions以及mRNA-ncRNA interactions。 其中有些lncRNA展现出广泛的trans interactions(反式相互作用)。这些lncRNA倾向于结合高表达的转录本,更有趣的是,这些lncRNA甚至即结合某些RNA转录...
越来越多研究表明,RNA–蛋白质互作网络在发育调控、免疫反应、肿瘤发生和神经退行性疾病中扮演着核心角色3,4。然而,RNA结构复杂、稳定性差、表达动态多变,给RNA–蛋白的互作研究带来诸多挑战。 近日,严健教授课题组在Advanced Genetics发表综述文章《D...
Figure 2. Replication and transcription of subgenomic RNAs by positive-sense RNA viruses. Panel (a) depicts the genome of an archetypal plant-infecting positive-sense RNA virus with two open reading frames shown for a replicase protein (larger solid gray box) and the coat protein (...
1.2 RNA virus and SARS-CoV-2 An RNA virus is a virus that utilizes RNA as its genetic material. Based on their genome and mode of replication, three distinct groups of RNA viruses have been classified: double-stranded RNA viruses (dsRNA), single-stranded RNA (ssRNA) and retroviruses [13,...
Hepatitis C virus RNA is 5′-capped with flavin adenine dinucleotide Hepatitis C virus utilizes flavin adenine dinucleotide as a non-canonical initiating nucleotide for the viral RNA polymerase, resulting in 5′ capping of viral RNA, which provides protection against the host innate immune response...
理解新冠RNA基因组的结构以及与之相互作用的宿主蛋白，可以帮助我们更好地开发治疗新冠的药物。近日，清华大学生命科学学院张强锋课题组与协和医学院王健伟课题组以及清华大学医学院丁强课题组合作，在Cell 杂志在线发表了题为“In vivo structural characterization of the SARS-CoV-2 RNA genome identifies host proteins ...
Phosphorylation of a nuclear condensate regulates cohesion and mRNA retention Here the authors study how interactions with nuclear speckles help localize mRNA in cells. They find that modifications of the proteins in these structures affects their cohesion and can modulate mRNA retention under stress. ...
2021年6月24日,扬州大学园艺与植物保护学院植物病毒学实验室贺振/张坤组在Genome Biology发表了题为“The dynamics of N6-methyladenine RNA modification in interactions between rice and plant viruses”的研究论文。该论文揭示了在水稻与病毒互...
推荐为探明多层菊形团胚胎性肿瘤(ETMR)的分子机制与治疗策略,研究人员对 11 例患者样本进行单细胞转录组和空间成像分析。发现其存在干细胞样与神经元样细胞层级,揭示 C19MC 调控干性、FGFR/Notch 通路驱动肿瘤。为 ETMR 靶向治疗提供关键依据。 论文解读 小儿脑肿瘤多层菊形团胚胎性肿瘤(ETMR)恶性程度极高,患者中位...