剪接、5'端加帽和3'端加尾被称为共转录事件(cotranscription events)或mRNA加工事件(mRNA processing events),它们在细胞核中完成。 剪接(splicing)即将初级转录物中的非编码序列去除。 1 断裂基因(Split genes) An interrupted gene (also called a split gene) is a g...
RNASEP(RNA splicing and processing factor)是一种重要的蛋白质,在真核生物中起着关键作用。它参与了RNA的剪接和加工过程,对细胞内基因表达的调控起着重要作用。RNASEP不仅在正常细胞中发挥作用,还在多种疾病中发挥作用等。对RNASEP进行相关研究不仅可以帮助我们更好地理解细胞内基因表达的调控机制,还可以为相关疾病...
参考文献 1.Guo,Y. E. et al. Pol II phosphorylation regulates a switch betweentranscriptional and splicing condensates.Nature(2019).doi:10.1038/s41586-019-1464-0 2. Mugler, C. F. et al. ATPaseactivity of the DEAD-box protein Dhh1 controls processing body formation.Elife5, (2016).3. Lin...
3'-splice site splicing junction spliceosome supramolecule small nuclear ribonucleoprotein, snRNP cleavage alternative splicing calcitonin calcitonin-gene related peptide, CGRP apolipoprotein B, ApoB cytosine deaminase differential RNA processing redundant gene t...
9. Kyburz A., et al., Direct interactions betweensubunits of CPSF and the U2 snRNP contribute to the coupling of pre-mRNA 3' endprocessing and splicing. Mol Cell, 2006, 23(2): 195-205. 10. Friend K., A.F. Lovejoy and J.A. Steitz, U2snRNP binds intronless histone pre-mRNAs ...
10.Wu, H. et al. Unusual Processing Generates SPA LncRNAs that Sequester Multiple RNA Binding Proteins. Mol Cell 64, 534-548, doi:10.1016/j.molcel.2016.10.007 (2016).11.Sahoo, T. et al. Prader-Willi phenotype caused by paternal deficiency for the HBII-85 C/D box small nucleolar ...
RNA splicing is a form of RNA processing in which a newly made precursor messenger RNA (mRNA) is transformed into a matureRNAby removing the non-coding sequences termed introns. The process of RNA splicing involves the removal of non-coding sequences or introns and joining of the coding sequ...
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12. Wang Y, Hu SB, Wang MR, Yao RW, Wu D, Yang L, Chen LL. Genome-wide screening of NEAT1 regulators reveals cross-regulation between paraspeckles and mitochondria.Nat Cell Biol. 2018 Oct;20(10):1145-1158 13. Chen LL. Ling-Ling Chen: Linking Long Noncoding RNA Processing and Funct...
近日，英国约翰英纳斯研究中心丁一倞团队在Genome Biology在线发表了题为In vivo nuclear RNA structurome reveals the RNA-structure regulation of mRNA processing in plants的研究论文，首次揭示了体内RNA二级结构对调控前体mRNA加工的作用。在该研究中，研究人员开发了拟南芥细胞核内RNA二级结构检测的新方法（图1），在...