Transcription – rRNA Processing Role of small nucleolar RNAs (snoRNAs) • snoRNPs associate with the rRNA before it is fully transcribed • guide snoRNAs participate in nucleotide modifications (vast majority, also of other molecules than rRNAs) and pre-rRNA cleavage ...
下周“BioArt生命科学前沿学者论坛”第九讲为RNA篇,时间是北京时间11月22日19:00,由中国科学院分子细胞科学卓越创新中心陈玲玲研究员报告,报告题目为:Linking RNA processing and function,届时欢迎大家参加直播。 讲座日程安排 演讲人:陈玲玲 研...
在原始转录本中,包括了不仅仅是编码区域,还包括了非编码区域,例如3'非翻译区域(3' untranslated region,3' UTR)和5'非翻译区域(5' untranslated region,5' UTR)。 后续处理(Post-Transcriptional Processing):在许多情况下,原始转录本需要经历后续处理,包括剪接(splicing)、5'端帽(5' capping)、3'端聚腺苷酸化...
RNA modifications have become hot topics recently. By influencing RNA processes, including generation, transportation, function, and metabolization, they act as critical regulators of cell biology. The immune cell abnormality in human diseases is also a research focus and progressing rapidly these years...
This work provides a comprehensive atlas of RNA modifications in human mitochondrial tRNAs and a list of 34 genes responsible for these modifications. Article CAS PubMed PubMed Central Google Scholar Hopper, A. K. & Nostramo, R. T. tRNA processing and subcellular trafficking proteins multitask...
RNA processing occurs in specialized subdomains of the nucleus. Processing events are initiated at the transcription sites, which are the first specialized nuclear subdomains, the “transcription factories.” Further modifications occur at distinct sites in the nucleus. Splicing can, for example, be ...
第八章RNA加工(RNAprocessing)RNAprocessing:anoverview RibosomeandrRNAprocessing tRNAprocessingmRNAprocessingPost-transcriptionalcontrolofgeneexpression 第一节RNA加工概述 一、断裂基因（Splitgenes）（一）定义 MosteukaryoticcodingregionofgenesareinterruptedbynoncodingDNA.Thecoding...
研究表明,m6A已知的最主要功能是调控mRNA的稳定性:胞质内经过m6A修饰的mRNA可以被YTHDF2识别,使其富集到Processing body(P-body)从而加速mRNA的降解。此外,m6A修饰还可以改变RNA的二级结构、调控microRNA的靶标识别来调控mRNA的稳定性。在核内,m6A修饰...
2. Proudfoot, N.J., Furger, A. & Dye, M.J. Integrating mRNA processing with tranion. Cell 108, 501-512 (2002). 3. Li, B. et al. RIP-PEN-seq identifies a class of kink-turn RNAs as splicing regulators. Nature Biotechnology 42, 119-131 (2024). ...
RNAs with enzymatic (specifically, catalytic) activity, such as the self-splicing molecules, are commonly referred to as ribozymes. Ribozymes have roles inreplication, mRNA processing, and splicing. By definition, these molecules can initiate their activities without the assistance of additional protein...