Transcription – rRNA Processing Role of small nucleolar RNAs (snoRNAs) • snoRNPs associate with the rRNA before it is fully transcribed • guide snoRNAs participate in nucleotide modifications (vast majority, also of other molecules than rRNAs) and pre-rRNA cleavage ...
RNA metabolism refers to any events in the life cycle of ribonucleic acid (RNA) molecules, including their synthesis, folding/unfolding, modification, processing and degradation. Related Subjects Alternative splicing RNA decay RNA editing RNA folding RNA modification RNA quality control RNA spli...
RNA processing occurs in specialized subdomains of the nucleus. Processing events are initiated at the transcription sites, which are the first specialized nuclear subdomains, the “transcription factories.” Further modifications occur at distinct sites in the nucleus. Splicing can, for example, be ...
RNA modifications have become hot topics recently. By influencing RNA processes, including generation, transportation, function, and metabolization, they act as critical regulators of cell biology. The immune cell abnormality in human diseases is also a research focus and progressing rapidly these years...
第八章RNA加工(RNAprocessing)RNAprocessing:anoverview RibosomeandrRNAprocessing tRNAprocessingmRNAprocessingPost-transcriptionalcontrolofgeneexpression 第一节RNA加工概述 一、断裂基因（Splitgenes）（一）定义 MosteukaryoticcodingregionofgenesareinterruptedbynoncodingDNA.Thecoding...
研究表明,m6A已知的最主要功能是调控mRNA的稳定性:胞质内经过m6A修饰的mRNA可以被YTHDF2识别,使其富集到Processing body(P-body)从而加速mRNA的降解。此外,m6A修饰还可以改变RNA的二级结构、调控microRNA的靶标识别来调控mRNA的稳定性。在核内,m6A修饰...
7. Alarcón, C. R., et al. "HNRNPA2B1 Is a Mediator of m(6)A-Dependent Nuclear RNA Processing Events. " Cell 162.6 (2015):1299-1308. 8. Alarcón, C. R., et al. "N6-methyladenosine marks primary microRNAs for processing." Nature 519.7544(2015):482....
RBPs参与的LLPS受多种因素的控制,包括环境刺激、翻译后修饰(post-translational modifications,PTMs)和mRNA修饰等(图1D)。进一步地,作者比较分析了PTMs在参与LLPS中的研究现状,PTMs修饰的位点是否存在于LLPS的结构区域、PTMs是否会影响RBPs的LLPS等仍是需要重点关注的生物学问题;同时作者分析了m6A RNA修饰对LLPS的...
and actin gene promoters. RNA Pol II promoters are responsible for the transcription of genes to produce precursors of all mRNA,microRNA, and most ofsmall nuclear RNAs.Primary transcriptsfrom RNA Pol II promoters undergo extensive posttranscriptional processing and modifications including 5′-capping, ...
研究表明,m6A已知的最主要功能是调控mRNA的稳定性:胞质内经过m6A修饰的mRNA可以被YTHDF2识别,使其富集到Processing body(P-body)从而加速mRNA的降解。此外,m6A修饰还可以改变RNA的二级结构、调控microRNA的靶标识别来调控mRNA的稳定性。在核内,m6A修饰可以调控RNA的剪接、出核过程,从而调控基因表达。m6A还可能与DNA甲...