Transcription – rRNA Processing Role of small nucleolar RNAs (snoRNAs) • snoRNPs associate with the rRNA before it is fully transcribed • guide snoRNAs participate in nucleotide modifications (vast major
RNA processing occurs in specialized subdomains of the nucleus. Processing events are initiated at the transcription sites, which are the first specialized nuclear subdomains, the “transcription factories.” Further modifications occur at distinct sites in the nucleus. Splicing can, for example, be ...
RNA modifications have become hot topics recently. By influencing RNA processes, including generation, transportation, function, and metabolization, they act as critical regulators of cell biology. The immune cell abnormality in human diseases is also a research focus and progressing rapidly these years...
This work provides a comprehensive atlas of RNA modifications in human mitochondrial tRNAs and a list of 34 genes responsible for these modifications. Article CAS PubMed PubMed Central Google Scholar Hopper, A. K. & Nostramo, R. T. tRNA processing and subcellular trafficking proteins multitask...
第八章RNA加工(RNAprocessing)RNAprocessing:anoverview RibosomeandrRNAprocessing tRNAprocessingmRNAprocessingPost-transcriptionalcontrolofgeneexpression 第一节RNA加工概述 一、断裂基因（Splitgenes）（一）定义 MosteukaryoticcodingregionofgenesareinterruptedbynoncodingDNA.Thecoding...
研究表明,m6A已知的最主要功能是调控mRNA的稳定性:胞质内经过m6A修饰的mRNA可以被YTHDF2识别,使其富集到Processing body(P-body)从而加速mRNA的降解。此外,m6A修饰还可以改变RNA的二级结构、调控microRNA的靶标识别来调控mRNA的稳定性。在核内,m6A修饰...
研究表明,m6A已知的最主要功能是调控mRNA的稳定性:胞质内经过m6A修饰的mRNA可以被YTHDF2识别,使其富集到Processing body(P-body)从而加速mRNA的降解。此外,m6A修饰还可以改变RNA的二级结构、调控microRNA的靶标识别来调控mRNA的稳定性。在核内,m6A修饰可以调控RNA的剪接、出核过程,从而调控基因表达。m6A还可能与DNA甲...
研究表明,m6A已知的最主要功能是调控mRNA的稳定性:胞质内经过m6A修饰的mRNA可以被YTHDF2识别,使其富集到Processing body(P-body)从而加速mRNA的降解。此外,m6A修饰还可以改变RNA的二级结构、调控microRNA的靶标识别来调控mRNA的稳定性。在核内,m6A修饰可以调控RNA的剪接、出核过程,从而调控基因表达。m6A还可能与DNA甲...
The RNA recognition motif (RRM), also known as the ribonucleoprotein (RNP) motif or RNP-type RNA-binding domain (RBD), is the most common RNA-binding motif that has been identified; it is present in a significant number of proteins involved in almost all aspects of RNA processing and trans...
研究表明,m6A已知的最主要功能是调控mRNA的稳定性:胞质内经过m6A修饰的mRNA可以被YTHDF2识别,使其富集到Processing body(P-body)从而加速mRNA的降解。此外,m6A修饰还可以改变RNA的二级结构、调控microRNA的靶标识别来调控mRNA的稳定性。在核内,m6A修饰可以调控RNA的剪接、出核过程,从而调控基因表达。m6A还可能与DNA甲...