S. Li, X. Ma, L. Zhang, Y. Zhang, W. Yao, X. Liang, J. Zhao, Z. Liu, X. Peng, H. Li, W. Tan, A core-shell structured COVID-19 mRNA vaccine with favorable biodistribution pattern and promising
“它适用于任何病毒,对任意病毒变种都广泛有效,对所有人群都是安全的。这可能是我们一直在寻找的通用疫苗形式。” Hai和他的同事在《PNAS》上发表了一篇题为“Live-attenuated virus vaccine defective in RNAi suppression induces rapid prote...
[4] Kimball S. Moderna expects at least $19 billion in COVID vaccine sales in 2022, reports big fourth-quarter earnings beat[EB/OL]. (2022-02-24)[2022-06-28]. https://www.cnbc.com/2022/02/24/covid-moderna-mrna-q4...
“它适用于任何病毒,对任意病毒变种都广泛有效,对所有人群都是安全的。这可能是我们一直在寻找的通用疫苗形式。” Hai和他的同事在《PNAS》上发表了一篇题为“Live-attenuated virus vaccine defective in RNAi suppression induces rapid protection in neonatal and adult mice lacking mature B and T cells”的论文...
[1] Fang E, Liu X, Li M, Zhang Z, Song L, Zhu B, Wu X, Liu J, Zhao D, Li Y. Advances in COVID-19 mRNA vaccine development. Signal Transduct Target Ther. 2022 Mar 23;7(1):94.[2] Obi P, Chen YG. The design and synthesis of circular RNAs. Methods. 2021 Dec; 196:85-...
还有一个问题:目前用于人体对抗COVID-19或其他疾病的RNA疫苗一般需要两剂才有效。考虑到其他多剂量疫苗的接种依从性较差,许多注射了第一剂的人可能不会注射第二剂。 新型递送系统有望解决这个问题。马萨诸塞州Vaxess技术公司的研究人员研发出了一种可穿戴的皮肤贴,上面布满丝样尖头的可溶微针,微针会缓慢地将疫苗送...
has recently become the molecule de nos jours. The reason is its role in covid-19 vaccines. The RNA molecules in these encode spike, a coronavirus protein. So, when the protein-making machinery of a body cell encounters such RNA, spike is what it makes. That lets a vaccine-recipient’s...
Hai和他的同事在《PNAS》上发表了一篇题为“Live-attenuated virus vaccine defective in RNAi suppression induces rapid protection in neonatal and adult mice lacking mature B and T cells”的论文,描述了这种疫苗策略是如何起作用的,并报告了它在小鼠身上的有效性。
Following the success of the COVID-19 vaccines, mRNA vaccines have now entered development for a wide range of infectious diseases. This Review discusses mRNA vaccine design considerations, delivery strategies and mechanisms of action, assessing mRNA vaccines currently in development for various viruses...
5. Sahin, U., Muik, A., Derhovanessian, E., Vogler, I., Kranz, L.M., Vormehr, M., Baum, A., Pascal, K., Quandt, J., Maurus, D., et al. (2020). COVID- 19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses. Nature 586, 594–599.6. Gajewski, T.F....