Pancreatic cancer (PC) is a very aggressive disease that is difficult to diagnose at an early stage. It progresses rapidly at a rate of about 1% per year [134,135]. Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive subtypes of PC, and late diagnosis and high heterogenei...
The clinical response rate to immune checkpoint blockade (ICB) therapy in melanoma remains low, despite its widespread use. Circular non-coding RNAs (circRNAs) are known to play a crucial role in cancer progression and may be a key factor limiting the ef
The use of molecular gene classifiers or signature scores is an attractive strategy to select cancer patients for treatment13,32. According to gene set variation analysis, most of the persistent clusters and cluster 10 showed enrichment of E2F target, G2M checkpoint, and MYC target genes (Supplem...
12,13]. An important impact of RNA editing is its ability to challenge the central dogma of biology. When RNA editing takes place in the coding sequence (CDS) region of an mRNA, where an I is recognized as a G or
Center for Anatomy and Cell Biology, Medical University of Vienna, A-1090 Vienna, Austria 2Max F. Perutz Laboratories, Department of Medical Biochemistry, Medical University of Vienna, A-1030 Vienna, Austria Advances in next-generation sequencing and mass spec- m6A methylation and adenosine to inos...
Introduction Follicular lymphoma (FL) initially presents as an indolent malignancy that frequently transforms to a more aggressive tumor. Multiple relapses after treatment are common, and responses to chemotherapy and immunotherapy are often transient. Mutations in genes for histone-modifying enzymes such ...
Introduction Follicular lymphoma (FL) is an incurable cancer arising from germinal B cells located within lymph nodes. It is a cancer with a complex clinical course—in some patients the disease progresses very slowly, while in some patients, termed “early relapsers”...
Cancer Computational biology and bioinformatics Download PDF Sections Figures References Abstract Introduction Results Discussion Conclusion Materials and methods Data availability References Acknowledgements Funding Author information Ethics declarations Additional information Supplementary Information Rights and permissions...
Introduction of a stop codon in a guide upstream of the cargo makes translation contingent on binding of an endogenous transcript to the guide, leading to ADAR editing of the stop codon and allowing translational readthrough. Through systematic sensor engineering, we achieve 277 fold improvement in...
Introduction Pharmaceutical nucleic acids have been long used in clinical and experimental medicine [1,2]. Among them, small interfering RNA (siRNA), antisense oligonucleotides (ASO), microRNA (miRNA), mRNA and clustered regularly interspaced short palindromic repeats-associated protein 9 (CRISPR/Cas9...