RNA与蛋白修饰综述:英文原版.pdf,JCB: Review Published Online: 4 April, 2016 | Supp Info: /10.1083/jcb.201511041 Downloaded from on March 30, 2018 Rapid and dynamic transcriptome regulation by RNA editing and RNA modifications 1 1,2 Konstantin Licht and M
A RNA SYNTHESIS PRIMED BY DNA There is a good deal of evidence that protein synthesis is accompanied by formation of a specific type of RNA called messenger RNA (mRNA) which receives the code for protein synthesis from DNA (see review of Hurwitz and August, 1963). The process of making mR...
Protein–RNA interactions have crucial roles in various cellular activities, which, when dysregulated, can lead to a range of human diseases. The identification of small molecules that target the interaction between RNA-binding proteins (RBPs) and RNA is
Starting with pioneering work on ribosomal proteins, studies of bacterial RBPs have paved the way for molecular studies of RNA–protein interactions. Work over the years has identified major RBPs that act on cellular transcripts at the various stages of bacterial gene expression and that enable ...
Two of the most widespread plant RNA-binding domains are the RNA Recognition Motif and the K Homology domain (see Table 1). The RNA Recognition Motif-containing protein family in particular is highly diversified within plants when compared to animals, with ∼50% of these proteins having no ...
processing, function, and decay of all other classes of RNA. There is growing evidence that protein activity can conversely be regulated by RNA1. Illustrating the importance of RBPs for cellular homeostasis, numerous diseases, including neurological disorders and cancer, have been linked to RBP ...
Specific interaction between RNA phage coat proteins and RNA. Prog. Nucleic Acid Res. Mol. Biol. 40, 185–220 (1991). CAS PubMed Google Scholar Stockley, P.G. et al. Probing sequence-specific RNA recognition by the bacteriophage MS2 coat protein. Nucleic Acids Res. 23, 2512–2518 (...
(FTD). Common mechanisms underlying aging and neurodegeneration involve dysregulated RNA metabolism and genome instability. Altered gene expression and proteinsynthesis has been shown to be associated with aging, as well as age-associated neurodegeneration. Protein abnormalities and inclusion bodies are ...
site of interest. In this review, we provide an overview of the current status of advances in RNA and RNA–protein therapy, with an emphasis on materials that have been developed for RNA delivery and applications of RNA-based drugs for the modulation of gene/protein expression and gene ...
HnRNP E1, also known as poly(rC)-binding protein (PCBP1)10, was reported to bind with AGO2 to stabilize miR-1, miR-133, and miR-206 in muscle cells (Fig. 4)38. Although this result was not obtained in cancer cells, it may suggest potential cancer-related roles for hnRNP E1 in re...