Skin punch biopsies were performed on PD patients diagnosed with the LRRK2 G2019S mutation and on control subjects with no known PD-related mutations or any other neurological disorder; additional mutant fibroblasts were purchased from Coriell (ND29370; Coriell Institute). Dermal fibroblasts grown ou...
5 Bio Imaging and Cell Dynamics Research Center, School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500-712, Korea. 6 Division of Pharmacology, Department of Molecular Cell Biology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, ...
Dr. Thomas Gasser of the Hertie Institute in Tuebingen, and the Coriell Institute for providing the cell lines and EMBL Gene Core at Heidelberg for support with high-throughput sequencing. The experiments presented in this paper were carried out using the HPC facilities of the University of ...
LRRK2 G2019S patient fibroblasts (PD1: ND29802 from 52-year-old male PD patient; PD2: ND33879 from 66 year old female PD patient) were purchased from Coriell Institute. Normal adult fibroblast (HDFa) was from Invitrogen. The fibroblasts were maintained in Minimum Essential Medium supplemented...