The CD20 inhibitors are also active in some autoimmune diseases and tumors. The major CD20 inhibitor is rituximab. Ocrelizumab and ofatumumab are humanized anti-CD20 monoclonal antibodies which are in clinical trial or marketed for diseases other than rheumatoid arthritis. Ibritumomab tiuxetan is the ...
MCE博客官网www.activeinhibitor.com 利妥昔单抗Rituximab是用于治疗某些自身免疫疾病和癌症类型的抗CD20嵌合单克隆抗体。 MCE 的所有产品仅用作科学研究,我们不为任何个人用途提供产品和服务 Rituximab利妥昔单抗的生物活性 体外研究 Rituximab利妥昔单抗抑制刺激的人B细胞的增殖,这与具有活化的幼稚表型的B细胞的相对增加...
Animal Administration 通过尾静脉注射将C57BL / 6小鼠(8-10周龄)接种于200μL盐水中的8×103 EL4-CD20 +细胞中。 在平行的小鼠组中,腹膜内接种150μg利妥昔单抗,鼠抗CD20 IgG2a Ab1F5或对照抗人IL-2R Ab daclizumab在300μL盐水或仅盐水中的接种。 24小时后。 MCE尚未独立确认这些方法的准确性。 它们仅...
Rituximab是一种人鼠嵌合性单克隆抗体,能特异性地与跨膜抗原CD20 结合。利妥昔单抗与B 细胞上的CD20 抗原结合后,启动介导B 细胞溶解的免疫反应。B 细胞溶解的可能机制包括:补体依赖的细胞毒作用(CDC),抗体依赖的细胞介导的细胞毒作用(ADCC)。研究发现,利妥昔单抗与B 细胞上的CD2...
Hepatitis B virus (HBV) reactivation, in some cases resulting in fulminant hepatitis, hepatic failure, and death, can occur in patients treated with drugs classified as CD20-directed cytolytic antibodies, including Rituxan. Cases have been reported in patients who are hepatitis B surface antigen (HB...
ACR, American College of Rheumatology; MTX, methotrexate; TNFi, tumor necrosis factor inhibitor.IMPORTANT SAFETY INFORMATION INDICATIONS Rituxan® (rituximab), in combination with methotrexate, is indicated for the treatment of adult patients with moderately to severely active rheumatoid arthritis (RA)...
Rituximab Pronunciation:ri-TUX-i-mab Generic name:rituximab Brand names:Rituxan,Riabni,Ruxience,Truxima Dosage form:injection for intravenous infusion (100 mg/10 mL, 500 mg/50 mL) Drug classes:Antirheumatics,CD20 monoclonal antibodies Medically reviewed byCarmen Pope, BPharm. Last updated on May ...
Rituximab (anti-CD20)抗体 Rituximab (anti-CD20) 是一种抗 CD20 嵌合单克隆抗体,用于某些自身免疫疾病和癌症的研究。 MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务 生物活性 体外研究 Rituximab anti-CD20 抑制受刺激的人 B 细胞的增殖,这与具有活化的幼稚表型的 B 细胞的相对...
Human Recombinant Monoclonal Antibody Supplier:Thermo Scientific MA547773 Catalog No.PIMA547773 $544.50/Each of 1 Qty Add to Cart Description Specificity: CD20 (Human B-lymphocyte-restricted differentiation antigen, Bp35), is a hydrophobic transmembrane protein with a molecular weight of ap...
These cells are known as CD20+ B-cells and are thought to be involved in GPA and MPA. Rituxan targets these cells and is thought to reduce their levels in the body. Because it is thought to interfere with B-cell function and disrupt ANCA production, Rituxan works differently from other ...