Recent research has shown the need for treatments for COX-2 mediated inflammation or inflammation-associated disorders. The prostaglandins are a class of biologically active lipid derivatives that have been identified as playing a role in mammalian inflammatory response. The inflammatory response is a lo...
Thus, in slow metabolizers, it can be inferred that the risks of taking codeine during pregnancy is lower. Nor should it be overlooked that opioids, as µ receptor agonists, increase the tone of intestinal smooth muscles having a constipating effect, as well as having emetic effect. All ...