Using conditional logistic regression analysis, odds ratios (ORs) for hip or knee replacement were estimated by comparing long-term (≥1year) nonselective NSAID use with long-term coxib use. Analyses were stati
Enkhe BadamgaravKevin KnightJames M. HenningLoren LaineElsevier Inc.GastroenterologyLaine L. Gastrointestinal effects of non-selective NSAIDs and Cox-2 selective inhibitors. Semin Arthritis Rheum 2002; 32 (Suppl 1):25-32.Laine L. The gastrointestinal effects of non- selective NSAIDs and COX-2-...
Cardiovascular events were infrequent and similar between celecoxib and non–COX-selective NSAIDs among patients>60 years old during a median follow-up of 3 years in theStandard Care vs Celecoxib Outcomes Trial(SCOT). "Our study results suggested that for patients with no history of cardiovascular ...
When patients receiving opioid therapy for pain engage in nonmedical opioid use (NMOU) or diversion, untoward consequences can occur. New evidence suggests that patients with cancer might be at a higher risk of NMOU than was previously thought, but clinical evidence still supports the use of ...
Long-term (chronic) use of non-steroidal anti-inflammatory drugs (NSAIDs) Warfarin sodium (Coumadin®, Jantoven®) Any medicine that contains heparin Clopidogrel (Plavix®) Selective serotonin reuptake inhibitors (SS...
This cohort study examines long-term risk of thromboembolism in patients with new-onset postoperative atrial fibrillation after first-time isolated
For patients who present with peptic ulcer bleeding but require NSAIDs long-term, H. pylori eradication therapy should be considered, followed by continuous proton pump inhibitor prophylaxis to prevent re-bleeding, regardless of which kind of NSAID (nonselective NSAID /coxib) is being prescribed. ...
Use of prescription-strength ibuprofen, naproxen and other commonly used pain relievers may be tied to a higher risk of heart failure, researchers report. Medicines like these fall into a category of painkillers known as non-steroidal anti-inflammatory drugs (NSAIDs). These medications may raise ...
Pharmacological interventions include the use of nonsteroidal anti-inflammatory drugs (NSAIDs) either locally or systemically, which are commonly used to alleviate mild to moderate pain in OA patients186,192. Intra-articular injection of corticosteroids can provide short-term pain relief in OA patients...
17. Graham DY, Agrawal NM, Campbell DR, Haber MM, Collis C, Lukasik NL, Huang B; NSAID-Associated Gastric Ulcer Prevention Study Group: Ulcer prevention in long-term users of nonsteroidal anti-inflammatory drugs: results of a double-blind, randomized, multicenter, active- and placebo- ...