Agents with specific biologic targets and limited toxicity require novel designs to dete... Z Wei,DJ Sargent,S Mandrekar - 《Statistics in Medicine》 被引量: 192发表: 2010年 Dose escalation trial designs based on a molecularly targeted endpoint Traditional phase I dose-finding studies for chemo...
Modern hierarchical organizations, like corporations, must motivate agents to work hard. Given their pyramid structure, it is not surprising that one commo... A Orrison,A Schotter,K Weigelt - 《Management Science》 被引量: 317发表: 2004年 A Survey of Experimental Research on . . . Tournament...
The HR remained increased, but was modified by adjustment for age, gender, comorbidity and prior fracture [dialysis group: 1.85 (95% CI: 1.75–1.95); renal transplanted group: 1.82 (95% CI: 1.62–2.06)]. Prescribed diuretics, lipid-modifying agents and proton pump inhibitors also modulated ...
Second, a fixed exchange rate regime to which economic agents attribute a certain probability of being abandoned, can generate the peso problem, as discussed in Chapter 3. The exchange rate remains stable while the regime is maintained, even with the expectation of exchange rate depreciation. There...
According to the preliminary data, apomorphine and phentolamine are possible future options for the treatment of ED; however, there needs to be further clinical evaluation of these agents. Initial data have shown that sildenafil can be successfully combined with intracavernosal injection in patients ...
The used disinfectants, cleaning agents shall comply with the requirements of environmental protection, to avoid contamination of soil, water, and environment. The public security organ at transitional resettlement sites shall strengthen security management and punish violations timely to maintain normal ...
e., the direct and isolated impacts of a scenario on a firm’s balance sheet—whereas macroprudential stress tests should include both first- and second-round effects—i.e., the indirect and interactive impacts of a scenario on a broad range of financial and non-financial sector agents [57]...
Enhanced understanding of molecular pathogenesis has enabled development of innovative biological agents that target specific parts of the immune system. These treatm... L Klareskog,AI Catrina,S Paget - 《Lancet》 被引量: 714发表: 2009年 Expression of cyclooxygenase 1 and cyclooxygenase 2 in human...
When the market is controlled by a smaller group of agents who are more homogeneous than the market as a whole, their commonality of outlook will tend to reduce the volatility of asset prices. But this will enable them, according to the Basle II rules, to leverage more, which will give ...
2015;3(6):461–71. Article PubMed Google Scholar Macchi C, Banach M, Corsini A, Sirtori CR, Ferri N, Ruscica M. Changes in circulating pro-protein convertase subtilisin/kexin type 9 levels–experimental and clinical approaches with lipid-lowering agents. Eur J Prev Cardiol. 2019;26(9):...