research suggesting statins do not reduce risk of Alzheimer's disease or improve cognition, published in Journal of Neurology - This interesting study contradicts previous research highlighting statins as a possible tool for reducing the risk of Alzheimer’s disease or slowing down its ...
To investigate developmental and vascular risk factors for Alzheimer's disease (AD), we examined 90 incident cases of probable AD in a cohort of 1859 individuals followed prospectively for six years. The presence of the APOE-ɛ4 allele was the strongest risk factor, and with increasing ...
Alzheimer's diseaseis the only one of the top 10 causes of death in the U.S. that cannot be prevented, treated or even slowed down. The greatest risk factors -- age, genes and family history -- are beyond our control. But that doesn't mean there's nothing you can do to improve y...
Visual impairment and cognitive dysfunction in Alzheimer’s disease. J Gen Intern Med. 1991;6(2):126-132. doi:10.1007/BF02598307 PubMedGoogle ScholarCrossref 42. Fischer ME, Cruickshanks KJ, Schubert CR, et al. Age-related sensory impairments and risk of cognitive ...
The greatest advantage of molecular network analysis is that it can be used to determine interactions among multiple factors that affect a correlation, based on a vast scientific literature, instead of focusing on one-dimensional relationships among a small number of factors. To infer the association...
of genetic risk factors in these two major forms of epilepsy. Spatial associations between topological changes and disease-related gene expression maps were evaluated against spatial permutation and “random-gene” null models37,38. Reproducibility of our findings was also assessed across sites, ...
1, 50 articles were excluded after screening the Abstract sections of the manuscripts. The full texts were then evaluated, and 29 additional articles were excluded due to duplication (one), meta-analysis (one), polymorphism for Alzheimer's disease (one), review (seven), other SNPs in CC3 (...
To elucidate the genetic underpinnings of the antidepressant efficacy of S-ketamine (esketamine) nasal spray in major depressive disorder (MDD), we performed a genome-wide association study (GWAS) in cohorts of European ancestry (n = 527). This ana
Risk factor combinations further amplify the odds of adverse psychosis outcomes. Conclusions: Reductions in the identified cannabis-related risks factors—short of abstinence—may decrease risks of related adverse psychosis outcomes, and thereby protect cannabis users’ health. Keywords: Cannabis psychosis...
The effect of apoE4 on HDL cholesterol differed with an analysis based on probands or on affected sib-pairs. The affected sib-pair model used adjust- ment for shared environment, type of LDL receptor gene muta- tion, and a proportion of additional genetic factors and may, therefore, be ...