The NKX3.l gene is affected by deletion and/or promoter hypermethylation in 90% of primary prostate cancers. NKX3.l acts as a transcription factor by binding directly to DNA. NKX3.l also complexes and coactivates other transcription factors such as serum response factor. We have now found ...
The risk of prostate cancer increases with age, and roughly 60% of cases are diagnosed after the age of 65.3It is uncommon before the age of 40. When seen in younger people, prostate cancer is often associated with a family history of the disease in relatives assigned male at birth or fa...
The results are presented as odds ratios (OR) with 95% confidence intervals (CI) by deciles of the ERS. All p-values given are two tails. Family history of PCa was not considered in this environmental score since it is not modifiable, and its effect was assessed as a separate factor. ...
Those who were following this diet and exercise program had lower levels of a growth factor called insulin-like growth factor (IGF-1) in their blood after 11 days. High IGF-1 has links to cancers, including prostate cancer. But not all studies have found a link between IGF-1 and ...
In some of the data sets I’ve looked at, upward of 70% to 80% of men with advanced prostate cancer will have hypertension. Obesity is another cardiovascular risk factor, it’s about one-third of the men we see. We try to do clinical trials of statins; however, they’re tough to ...
African ancestry is a significant risk factor for prostate cancer and advanced disease. Yet, genetic studies have largely been conducted outside the context of Sub-Saharan Africa, identifying 278 common risk variants contributing to a multiethnic polygen
cancer never have symptoms, undergo no therapy, and eventually die of other causes. Whether and how to treat localized prostate cancer is thus a difficult decision, and depends largely upon an appraisal of the aggressiveness of the tumor and the likelihood that the cancer will spread to other ...
17 If vasectomy were associated with increased numbers of partners and a sexually transmitted infection were a risk factor for prostate cancer, this would be a potential confounder of the association between vasectomy and prostate cancer. While no association between a history of a sexually ...
Purpose To report treatment outcomes in a cohort of extreme-risk prostate cancer patients and identify a subgroup of patients with worse prognosis. Materials and methods Extreme-risk prostate cancer patients were defined as patients with at least one extreme-risk factor: stage cT3b–cT4, Gleason ...
of prostate cancer has been established as an important risk factor, and recent research supports and points to the existence of a subgroup of prostate cancer families with a hereditary form of the disease. Diet is another well-known risk factor. Recently, it has become evident that nutritional...