There are molecular changes that are common to two conditions, thus justifying the fact of Crohn's disease being a risk factor for colorectal carcinoma. The disease control with an appropriate therapy and with surveillance are two ways to control this risk. A proinflammatory state is the ...
Obesity is a risk factor for colorectal cancer. However, the effect of body weight change on colorectal cancer is uncertain. This study aimed to investigate the relationship between difference in body mass index and the risk of colorectal cancer. In this nationwide population-based cohort study, p...
Colorectal cancer often starts with few, if any, noticeable symptoms in its early stages. Consult with a healthcare professional if you experience any changes in bowel habits, changes in the consistency or calibre of stools, rectal bleeding, abdominal discomfort, unexplained weight loss...
Colorectal cancer. Lancet. 2014;383(9927):1490-1502. doi:10.1016/S0140-6736(13)61649-9 PubMedGoogle ScholarCrossref 2. NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416...
Somatic superenhancer duplications and hotspot mutations lead to oncogenic activation of the KLF5 transcription factor. Cancer Discov. 8, 108–125 (2018). Article CAS PubMed Google Scholar Giannakis, M. et al. Genomic correlates of immune-cell infiltrates in colorectal carcinoma. Cell Rep. 15, ...
In the epidemiology of colorectal cancer, the age factor is manifested very strongly as a basic (endogenous) risk factor. Up to 90% of all colorectal cancers have been diagnosed in the population older than 50 years of age [8], [11], [12]. Considering this figure, we decided to study...
The present study identified a new genetic factor for CRC risk and an interaction between CDH13 and APN in CRC risk. These genetic factors may be useful for predicting CRC risk.Background Colorectal cancer (CRC) is the third most common cancer in men and the second among women worldwide [...
The present study identified a new genetic factor for CRC risk and an interaction between CDH13 and APN in CRC risk. These genetic factors may be useful for predicting CRC risk.Background Colorectal cancer (CRC) is the third most common cancer in men and the second among women worldwide [...
Tobacco smoking is suggested as a risk factor for colorectal cancer (CRC), but the complex relationship and the potential pathway are not fully understood. We performed two-sample Mendelian randomisation (MR) analyses with genetic instruments for smoking
Family history of cancer as a potential risk factor for colorectal cancer in EMRO countries: a systematic review and meta-analysis Article Open access 14 October 2023 Main At least four large record linkage and cohort studies (Ekbom et al, 1993; Goldbohm et al, 1993; Johansen et al, 199...