The TRIM superfamily exhibits a highly conserved order of domains in the RBCC motif, comprising a RING domain, one or two B-box (BB) domains, and a coiled-coil (CC) domain.31The BB domains of TRIMs are also zinc
A RING Finger Protein is a type of E3 ubiquitin ligase that contains a RING finger domain, which is a folded domain consisting of seven cysteine residues and one histidine residue binding two zinc ions. This domain is critical for the transfer of ubiquitin to substrates or to other RING finge...
According to domain organization and the ability to carry thioester-linked Ub, E3 ligases can be divided into 4 types: HECT, RING, U-box, and RBR4. RING-type E3 ligases are characterized by the presence of a RING domain, which was first identified in a protein encoded by the Really ...
We previously reported that the Plasmodium falciparum putative serine/threonine protein phosphatase 7 (PP7) is a high-confidence substrate of the cAMP-dependent protein kinase (PKA). Here we explore the function of PP7 in asexual P. falciparum blood stage parasites. We show that conditional disrup...
(16) show that mutations of the RING finger resulted in the retention of the RET finger protein in the cytoplasm even though the putative nuclear localization signal was intact. These studies suggest that the RING finger plays a role in nuclear targeting. When the RING motif of the RUSH gene...
This protein is synthesized in the cytoplasm with an unusually long (~ 120 amino acid) mitochondrial leader sequence that targets it to the inner membrane space [21]. The mature protein is a homodimer without bound cofactor. The structures of both human [38] and yeast (which is a ...
At2g19410 U-box domain-containing protein kinase family protein Protein ubiquitination −0.58 n.c. L At1g32850 UBP11, UBIQUITIN-SPECIFIC PROTEASE11 Ubiquitin-dependent protein catabolic process −0.55 n.c. L At4g22285 Ubiquitin C-terminal hydrolases superfamily protein Ubiquitin-dependent protein ...
The E3 enzymes are grouped into three families based on the presence of the E3 catalytic core domain: the homology to E6AP carboxyl terminus (HECT), the really interesting novel gene (RING) finger (RNF) and the U-box protein families [12]. The HECT domain is comprised of approximately ...