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Cross-resistance between rifampicin and KRM-1648 is associated with specific rpoB alleles in Mycobacterium tuberculosis. Int J Tuberc Lung Dis 6: 166–170 (2002) 20. Wichelhaus TA, Schafer V, Brade V, Boddinghaus B. Molecular characterization of rpoB mutations conferring cross-resistance to ...
Rifampin belongs to a group of antibiotics known as rifamycins which kill bacteria (bactericidal) by preventing bacterial RNA synthesis. Rifampin binds to the bacterial DNA-dependent RNA polymerase, an enzyme that is essential for the transcription of DNA into RNA, and prevents the elongation or RN...
Five patients aborted the rifampin treatment because of adverse effects and continued with monotherapy. All five had complete remission. These patients were not included in the final analysis.ConclusionsOur study has not proven a statistically significant advantage by adding rifampicin to the antibiotic ...
oral administrationrifampicintuberculosisworkersThese workers at Turku, Finland, gave an oral dose of 450 mg rifampicin to normal subjects in a crossover study, either as a single tablet or in the form of three 150 mg gelatin capsules, and assayed the drug in the blood after 1.2, 4, 6 and...
Few effective therapeutic options are available for treating severe infections caused by extensively drug-resistant Acinetobacter baumannii (XDR-AB). Using a murine thigh-infection model, we examined the in vivo efficacy of colistin in combination with m
M. (1973) Kinetics and mechanisms of drug action on microorganisms XVII: Bactericidal effects of penicillin, kanamycin, and rifampicin with and without organism pretreatment with bacteriostatic chloramphenicol, tetracycline, and novobiocin. J. Pharm. Sci. 62: pp. 1666-1673...
The relative susceptibility of intestinal and hepatic cytochrome P450 (CYP) 3A to induction by rifampin (INN, rifampicin), as a function of age and sex, was investigated with the CYP3A substrate midazolam. Methods. Fourteen young women (mean age, 26 +/- 4 years), 14 young me...
GeneXpert MTB/RIF has revolutionized the tuberculosis diagnosis by simultaneous detection of Mycobacterium tuberculosis and resistance to RIF (rifampicin), a surrogate marker for multidrug-resistant TB in less than two hours. The RIF-resistance pattern in Balochistan, Pakis...