The usual dose is 10 mg/kg per day (up to 600 mg per day). Rifampicin is a potent hepatic enzyme inducer and has many clinically significant drug interactions affecting the dosing of other medications, such as warfarin sodium (Coumadin), theophylline, and HIV protease inhibitors, nevirapine ...
Because there is a limit to the rate at which the liver can deliver the drug to the bile, the elimination half-life after a 600 mg dose rises to 3 h and may be as long as 5 h with a 900 mg dose. The desacetyl compound is mainly found in the bile, where the parent compound ...
The median daily dosages of rifampicin and levofloxacin were, respectively, 1,200 mg (range 300-2,100) and 750 mg (range 500-1,500), corresponding to a mean daily dose per kg of, respectively, 16.2卤4.3 mg/kg and 10.1卤3.0 mg/kg. After a mean follow-up period of 55.6卤27.1 ...
Adults: 10mg/kg per day, no more than 600mg per day, taken before meals.According to the domestic clinical experience, the maximum daily dose should not exceed 1.2g, but there is no sufficient clinical research data to support it. Children: 10-20mg/kg, no more than 600mg per day, oral...
OrganismTest TypeRouteReported Dose (Normalized Dose)EffectSource guinea pig LD50 intraperitoneal 639mg/kg (639mg/kg) ? Antibiotica et Chemotherapia Vol. 16, Pg. 316, 1970. human TDLo oral 180mg/kg (180mg/kg) SENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYE SENSE ORGANS AND SPEC...
The drug was given in a dose of 10-12 mg/kg per day divided into two equal parts, for 7 days. No untoward side effects were observed. Our experience should encourage the use of this agent in controlling outbreaks of shigellosis and in curing resistant Shigella spp. infections where other ...
8. Patients with impaired liver function often need to reduce the dose, and the daily dose is ≤8mg/kg. 9. People with impaired renal function do not need to reduce the dose.There was no significant change in the blood concentration of rifampicin in patients with reduced glomerular filtration...
8. Patients with liver dysfunction often need to reduce the dose, daily dose ≤ 8 mg / kg. 9. There is no need to reduce the dosage in patients with renal dysfunction. There was no significant change in plasma concentration of rifampicin in patients with decreas...
The use of rifampicin, a bactericidal antibiotic drug commonly used to treat tuberculosis, in the management of psoriasis is examined. Studies show that doses of 300-600mg per day of rifampicin, in combination with other treatments and over varying periods of time, can improve symptoms in some...
Eligible participants were screened within 9 days before receiving the first dose. Participants orally received either SOC or ganfeborole 1–30 mg QD. SOC (Rifafour e-275 or generic alternative) was weight adjusted per the South African National Tuberculosis Management Guidelines 2014 (ref. 33)...