About 30–50% of the dose can be recovered from the feces. Elimination from plasma is biphasic, with a terminal half-life of 45 h. The drug is a weak inducer of hepatic enzymes. The rate of metabolism increases, and the plasma area under the concentration–time curve (AUC) declines as...
Efficacy and safety of rifabutin-containing 'rescue therapy' for resistant Helicobacter pylori infection. T. J. BORODY*, G. PANG*, A. R. WETTSTEIN, ... TJ Borody,G Pang,AR Wettstein,... - 《Aliment Pharmacol Ther》 被引量: 279发表: 2006年 Adverse events associated with high-dose rifa...
Oral administration of single doses of rifabutin 300 to 900mg to male patients with human immunodeficiency virus (HIV) infection resulted in mean maximum plasma concentrations of 0.37 to 0.9 mg/L. Mean absolute bioavailability is about 20% after a single dose. The area under the rifabutin plasma...
Rifabutin-based high- dose proton-pump inhibitor and amoxicillin triple regi- men as the rescue treatment for Helicobacter pylori [J]. Helicohacter, 2014,19 455 -- 461.Lim HC, Lee YJ, An B et al. Rifabutin-based high-dose proton-pump inhibitor and amoxicillin triple regimen as the rescue...
Dose-limiting toxicity of rifabutin in AIDS-related complex: syndrome of arthralgia/arthritis. We studied the tolerance of humans to rifabutin, a rifamycin with antimycobacterial and in vitro anti-HIV activity. Sixteen subjects with AIDS-related comp... FP Siegal,D Eilbott,H Burger,... - 《...
pylori infection, almost all studies have administered rifabutin 300mg/day; this dose seems to be more effective than 150mg/day. The ideal length of ... Gisbert,P Javier,Calvet,... - 《Alimentary Pharmacology & Therapeutics》 被引量: 279发表: 2012年 Association between Acquired Rifamycin Resi...
as a first-line or rescue treatment for H. pylori. The purpose of this study was to evaluate the efficacy and safety of dual therapy vesus rifabutin-containing triple therapy versus classical bismuth-containing quadruple therapy as rescue therapy for the eradication of refractory Helicobacter pylori...
For treating H. pylori infection, almost all studies have administered rifabutin 300 mg/day; this dose seems to be more effective than 150 mg/day. The ideal length of treatment remains unclear, but 10- to 12-day regimens are generally recommended. The mean rate ...
pylori infection, almost all studies have administered rifabutin 300mg/day; this dose seems to be more effective than 150mg/day. The ideal length of ... Gisbert,P Javier,Calvet,... - 《Alimentary Pharmacology & Therapeutics》 被引量: 280发表: 2012年 ...
S1342Efficacy of H. pylori Eradication by Low-Dose Rifabutin Triple Therapy (RHB-105) Is Unaffected by BMI: Post-hoc Analysis From Two Phase 3 Trialsdoi:10.14309/01.ajg.0000707416.27079.6aSheldon, Kely L.Moss, StevenAl Samman, Mohd Amer...