Together, our results indicate that ribotoxic stress activates the human pyrin inflammasome through a mechanism that requires p38 MAPK signaling and microtubule stability.doi:10.1074/jbc.M112.448795Yu, J.-W.Farias, A.Hwang, I.Fernandes-Alnemri, T....
Mechanistically, ribotoxic stress activates the JNK-USP36 signaling to stabilize Snail1 in the nucleolus, which facilitates ribosome biogenesis and tumor cell survival. Furthermore, we show that HHT activates the JNK-USP36-Snail1 axis in solid tumor cells, but not in leukemia cells, resulting in...
Ribotoxic stressors share a common mechanism in that they require ZAK, an upstream MAP3K, to activate the pro-apoptotic and proinflammatory signaling pathways that lie downstream of SAPKs. By employing siRNA mediated knockdown of ZAK or administration of sorafenib and nilotinib, kinase inhibitors ...
While it is recognized that DON-induced RSR involves protein phosphorylation and that DON targets the ribosome, a comprehensive assessment of how these events contribute to signaling, modulation of ribosome function and regulation of key biological processes is lacking.Pan, Xiao...
(JNKs) are classic stress-activated protein kinases.Many cellular stresses have beenshown to stimulate JNK activation.In this review,we focus on ribotoxic stresses based on their multiple biologicalpotencies including anti-HIV-1 activity.Some of the functions of ribotoxins and the signaling ...
The ribotoxic stress response is a pathway that gets activated when ribosomes get impaired, leading to disruptions in protein synthesis, increased inflammatory signaling, and cell death if left unresolved.Taraxacumcan induce apoptosis-associated ribosomal RNA (rRNA) cleavage, however, the exact working...
Our findings suggest that targeting the RSR may be neuroprotective in patients with ALS/FTD caused by repeat expansion in C9ORF72.doi:10.1126/scisignal.adl1030Daoyuan DongZhe ZhangYini LiMalgorzata J. LatalloShaopeng WangBlake NelsonRong WuGopinath KrishnanFen-Biao GaoBin WuScience Signaling...
Early phosphoproteomic changes in the mouse spleen during deox- ynivalenol-induced ribotoxic stress. Toxicol. Sci. 135, 129-143. http://www. ncbi.nlm.nih.gov/pubmed/23811945PAN, X., WHITTEN, D. A., WU, M., CHAN, C., WILKERSON, C. G. & PESTKA, J. J. 2013a. Early ...
Some of the functions of ribotoxins and the signaling transduction pathway that mediated are mentioned. Different from other stimulators, ribotoxic stresses act on special motifs of 28S rRNA in translationally active mammal ribosomes. Binding and damaging on the motif leads to JNK activation and ...
TIF-IA is a basal transcription factor of RNA polymerase I (Pol I) that is a major target of the JNK2 signaling pathway in response to ribotoxic stress. Using advanced fluorescence microscopy and kinetic modeling we elucidated the subcellular localization of TIF-IA and its exchange dynamics ...